Diederik van de Beek

Research interests

Publications

• Proceedings of the National Academy of Sciences

  Journal · 2024 · https://doi.org/10.1073/pnas

• The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

  Proceedings of the National Academy of Sciences · 2022 · https://doi.org/10.1073/pnas.2200413119

• Human genetic and immunological determinants of critical COVID-19 pneumonia

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04447-0

• Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

  Science Immunology · 2021 · https://doi.org/10.1126/sciimmunol.abl4340

• Autoantibodies against type I IFNs in patients with life-threatening COVID-19

  Science · 2020 · https://doi.org/10.1126/science.abd4585

• Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

  Science · 2020 · https://doi.org/10.1126/science.abd4570

• ESCMID guideline: diagnosis and treatment of acute bacterial meningitis

  Clinical Microbiology and Infection · 2016 · https://doi.org/10.1016/j.cmi.2016.01.007

• 2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis*

  Clinical Infectious Diseases · 2016 · https://doi.org/10.1093/cid/ciw861

• Systemic inflammation and microglial activation: systematic review of animal experiments

  Journal of Neuroinflammation · 2015 · https://doi.org/10.1186/s12974-015-0332-6

• Corticosteroids for acute bacterial meningitis

  Cochrane Database of Systematic Reviews · 2015 · https://doi.org/10.1002/14651858.cd004405.pub5

• Brain Abscess

  New England Journal of Medicine · 2014 · https://doi.org/10.1056/nejmra1301635

• Clinical characteristics and outcome of brain abscess

  Neurology · 2014 · https://doi.org/10.1212/wnl.0000000000000172

• The immunology of acute stroke

  Nature Reviews Neurology · 2012 · https://doi.org/10.1038/nrneurol.2012.98

• Post-stroke infection: A systematic review and meta-analysis

  BMC Neurology · 2011 · https://doi.org/10.1186/1471-2377-11-110

• Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

  Clinical Microbiology Reviews · 2010 · https://doi.org/10.1128/cmr.00070-09

• Systemic infection and delirium: when cytokines and acetylcholine collide

  The Lancet · 2010 · https://doi.org/10.1016/s0140-6736(09)61158-2

• Community-Acquired Bacterial Meningitis in Adults

  New England Journal of Medicine · 2006 · https://doi.org/10.1056/nejmra052116

• Clinical Features and Prognostic Factors in Adults with Bacterial Meningitis

  New England Journal of Medicine · 2004 · https://doi.org/10.1056/nejmoa040845

• Dexamethasone in Adults with Bacterial Meningitis

  New England Journal of Medicine · 2002 · https://doi.org/10.1056/nejmoa021334

Current projects

No projects listed.