Issei Komuro

Research interests

Publications

• Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01233-6

• A cross-population atlas of genetic associations for 220 human phenotypes

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00931-x

• Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0705-3

• JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ―

  Circulation Journal · 2019 · https://doi.org/10.1253/circj.cj-19-0342

• p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

  Cell Metabolism · 2012 · https://doi.org/10.1016/j.cmet.2011.12.006

• Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

  Nature · 2012 · https://doi.org/10.1038/nature10992

• A crucial role for adipose tissue p53 in the regulation of insulin resistance

  Nature Medicine · 2009 · https://doi.org/10.1038/nm.2014

• Vascular Cell Senescence

  Circulation Research · 2007 · https://doi.org/10.1161/01.res.0000256837.40544.4a

• p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

  Nature · 2007 · https://doi.org/10.1038/nature05602

• G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes

  Nature Medicine · 2005 · https://doi.org/10.1038/nm1199

• Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

  Nature Cell Biology · 2004 · https://doi.org/10.1038/ncb1137

• Adult Cardiac Sca-1-positive Cells Differentiate into Beating Cardiomyocytes

  Journal of Biological Chemistry · 2004 · https://doi.org/10.1074/jbc.m310822200

• Endothelial Cell Senescence in Human Atherosclerosis

  Circulation · 2002 · https://doi.org/10.1161/01.cir.0000013836.85741.17

• Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

  Nature Genetics · 2001 · https://doi.org/10.1038/90123

• Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

  Nature Genetics · 1999 · https://doi.org/10.1038/6023

• Growth Hormone and Prolactin Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrate-1, -2, and -3, Their Association with p85 Phosphatidylinositol 3-Kinase (PI3-kinase), and Concomitantly PI3-kinase Activation via JAK2 Kinase

  Journal of Biological Chemistry · 1998 · https://doi.org/10.1074/jbc.273.25.15719

• Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

  Journal of Biological Chemistry · 1998 · https://doi.org/10.1074/jbc.273.9.5315

• Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

  Journal of Clinical Investigation · 1997 · https://doi.org/10.1172/jci119709

• Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

  Nature · 1997 · https://doi.org/10.1038/36369

• Angiotensin II Partly Mediates Mechanical Stress–Induced Cardiac Hypertrophy

  Circulation Research · 1995 · https://doi.org/10.1161/01.res.77.2.258

• Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

  Proceedings of the National Academy of Sciences · 1993 · https://doi.org/10.1073/pnas.90.17.8145

• Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

  FEBS Letters · 1988 · https://doi.org/10.1016/0014-5793(88)80489-7

Current projects

No projects listed.