E. John Wherry

Research interests

Publications

• Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

  Science Immunology · 2021 · https://doi.org/10.1126/sciimmunol.abi6950

• mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

  Science · 2021 · https://doi.org/10.1126/science.abm0829

• Comprehensive mapping of immune perturbations associated with severe COVID-19

  Science Immunology · 2020 · https://doi.org/10.1126/sciimmunol.abd7114

• Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

  Science · 2020 · https://doi.org/10.1126/science.abc8511

• CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

  Annual Review of Immunology · 2019 · 10.1146/annurev-immunol-041015-055318

• Defining ‘T cell exhaustion’

  Nature reviews. Immunology · 2019 · https://doi.org/10.1038/s41577-019-0221-9

• TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

  Nature · 2019 · 10.1038/s41586-019-1325-x

• Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

  Nature Medicine · 2018 · 10.1038/s41591-018-0010-1

• Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

  Nature · 2018 · 10.1038/s41586-018-0392-8

• T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

  Nature · 2017 · 10.1038/nature22079

• Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

  Science · 2016 · 10.1126/science.aaf2807

• Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

  Cell · 2016 · 10.1016/j.cell.2016.11.022

• Molecular and cellular insights into T cell exhaustion

  Nature reviews. Immunology · 2015 · 10.1038/nri3862

• Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

  Nature · 2015 · 10.1038/nature14292

• T cell exhaustion

  Nature Immunology · 2011 · 10.1038/ni.2035

• Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.

  PubMed · 2011 · 10.1031/ni.2131

• Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

  Nature Immunology · 2011 · 10.1038/ni.2131

• Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

  Nature Immunology · 2008 · 10.1038/ni.1679

• The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

  Nature Immunology · 2007 · 10.1038/ni1443

• Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

  Immunity · 2007 · 10.1016/j.immuni.2007.09.006

• Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

  Immunity · 2007 · 10.1016/j.immuni.2007.11.006

• PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

  Nature · 2006 · 10.1038/nature05115

• Restoring function in exhausted CD8 T cells during chronic viral infection

  Nature · 2005 · 10.1038/nature04444

• Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

  Nature Immunology · 2005 · 10.1038/ni1268

• Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

  Nature Immunology · 2003 · 10.1038/ni1009

• Lineage relationship and protective immunity of memory CD8 T cell subsets

  Nature Immunology · 2003 · 10.1038/ni889

• Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

  Journal of Virology · 2003 · 10.1128/jvi.77.8.4911-4927.2003

• Effector and memory T-cell differentiation: implications for vaccine development

  Nature reviews. Immunology · 2002 · 10.1038/nri778

Current projects

No projects listed.