Jonathan J. Miner

Research interests

Publications

• TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

  Cell Reports · 2020 · 10.1016/j.celrep.2020.03.056

• STING-associated lung disease in mice relies on T cells but not type I interferon

  Journal of Allergy and Clinical Immunology · 2019 · 10.1016/j.jaci.2019.01.044

• STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

  The Journal of Experimental Medicine · 2019 · 10.1084/jem.20182192

• Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ

  Nature Microbiology · 2019 · 10.1038/s41564-019-0416-7

• Tofacitinib for refractory uveitis and scleritis

  American Journal of Ophthalmology Case Reports · 2018 · 10.1016/j.ajoc.2018.12.001

• Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

  Proceedings of the National Academy of Sciences · 2018 · 10.1073/pnas.1806239115

• Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice

  Science Translational Medicine · 2018 · 10.1126/scitranslmed.aao7090

• Zika Virus Pathogenesis and Tissue Tropism

  Cell Host & Microbe · 2017 · 10.1016/j.chom.2017.01.004

• STING-associated vasculopathy develops independently of IRF3 in mice

  The Journal of Experimental Medicine · 2017 · 10.1084/jem.20171351

• Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis

  Science Translational Medicine · 2017 · 10.1126/scitranslmed.aah3438

• Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

  The Lancet Infectious Diseases · 2017 · https://doi.org/10.1016/s1473-3099(16)30385-1

• Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero

  Cell Host & Microbe · 2017 · 10.1016/j.chom.2017.08.012

• Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears

  Cell Reports · 2016 · 10.1016/j.celrep.2016.08.079

• A Mouse Model of Zika Virus Pathogenesis

  Cell Host & Microbe · 2016 · https://doi.org/10.1016/j.chom.2016.03.010

• A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

  Nature · 2016 · 10.1038/nature18625

• Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.05.008

• The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

  Nature Medicine · 2015 · 10.1038/nm.3974

• Brief Report: Chikungunya Viral Arthritis in the United States: A Mimic of Seronegative Rheumatoid Arthritis

  Arthritis & Rheumatology · 2015 · 10.1002/art.39027

• Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier

  Current Opinion in Immunology · 2015 · 10.1016/j.coi.2015.10.008

• Cardiac Manifestations of Systemic Lupus Erythematosus

  Rheumatic Disease Clinics of North America · 2013 · 10.1016/j.rdc.2013.10.003

• E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling

  Blood · 2010 · 10.1182/blood-2009-12-259556

• Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF

  Journal of Clinical Investigation · 2008 · 10.1172/jci35754

• Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow

  Blood · 2008 · 10.1182/blood-2008-04-149468

• Galectin-1 Induces Reversible Phosphatidylserine Exposure at the Plasma Membrane

  Molecular Biology of the Cell · 2008 · 10.1091/mbc.e08-07-0786

• The discovery of aspirin's antithrombotic effects.

  PubMed · 2007

Current projects

No projects listed.