John E. Shively

Research interests

Publications

• Tailoring the Pharmacokinetics and Positron Emission Tomography Imaging Properties of Anti–Carcinoembryonic Antigen Single-Chain Fv-Fc Antibody Fragments

  Cancer Research · 2005 · 10.1158/0008-5472.622.65.2

• 124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice.

  PubMed · 2003

• High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.150228297

• Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers

  Immunotechnology · 1996 · 10.1016/1380-2933(95)00027-5

• Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts.

  PubMed · 1996

• A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

  Nature · 1992 · https://doi.org/10.1038/356768a0

• Human Aromatase: cDNA Cloning, Southern Blot Analysis, and Assignment of the Gene to Chromosome 15

  DNA · 1988 · 10.1089/dna.1988.7.27

• Hormone-Sensitive Lipase: Sequence, Expression, and Chromosomal Localization to 19 cent-q13.3

  Science · 1988 · 10.1126/science.3420405

• Insulin-Like Growth Factor (IGF) Binding Protein Complementary Deoxyribonucleic Acid from Human HEP G2 Hepatoma Cells: Predicted Protein Sequence Suggests an IGF Binding Domain Different from Those of the IGF-I and IGF-II Receptors

  Molecular Endocrinology · 1988 · 10.1210/mend-2-5-404

• Hormonal Regulation, Tissue Distribution, and Content of Aromatase Cytochrome P450 Messenger Ribonucleic Acid and Enzyme in Rat Ovarian Follicles and Corpora Lutea: Relationship to Estradiol Biosynthesis*

  Endocrinology · 1988 · 10.1210/endo-122-4-1426

• Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

  Proceedings of the National Academy of Sciences · 1987 · 10.1073/pnas.84.2.407

• Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family.

  Proceedings of the National Academy of Sciences · 1987 · 10.1073/pnas.84.4.920

• Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase.

  Journal of Biological Chemistry · 1986 · 10.1016/s0021-9258(18)66758-4

• Cea-related antigens: Molecular biology and clinical significance

  Critical Reviews in Oncology/Hematology · 1985 · 10.1016/s1040-8428(85)80008-1

• Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

  Journal of Biological Chemistry · 1985 · 10.1016/s0021-9258(18)88984-0

• The amino acid sequence of a fluorescein-labeled peptide from the active site of (Na,K)-ATPase.

  Journal of Biological Chemistry · 1984 · 10.1016/s0021-9258(17)42732-3

• C21 steroid side chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17 alpha-hydroxylase/C17,20-lyase cytochrome P-450.

  Journal of Biological Chemistry · 1984 · 10.1016/s0021-9258(17)43191-7

• Isolation and Characterization of a Full-Length Expressible cDNA for Human Hypoxanthine Phosphoribosyltransferase

  CaltechAUTHORS (California Institute of Technology) · 1983

• Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

  Proceedings of the National Academy of Sciences · 1983 · 10.1073/pnas.80.2.477

• A novel active pentapeptide from chicken brain identified by antibodies to FMRFamide

  Nature · 1983 · 10.1038/305328a0

• Microsequence analysis of peptides and proteins

  Analytical Biochemistry · 1982 · 10.1016/0003-2697(82)90351-7

• Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules.

  The Journal of Experimental Medicine · 1982 · 10.1084/jem.156.2.550

• Microsomal cytochrome P-450 from neonatal pig testis: two enzymic activities (17.alpha.-hydroxalase and C17,20 associated with one protein

  Biochemistry · 1981 · 10.1021/bi00517a014

• Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.

  Proceedings of the National Academy of Sciences · 1980 · 10.1073/pnas.77.8.5021

• Formation of anhydrosugars in the chemical depolymerization of heparin

  Biochemistry · 1976 · https://doi.org/10.1021/bi00663a005

Current projects

No projects listed.