Richard J. Lewis

Research interests

Publications

• Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis

  Frontiers in Ecology and Evolution · 2019 · 10.3389/fevo.2019.00218

• Conotoxins: Chemistry and Biology

  Chemical Reviews · 2019 · 10.1021/acs.chemrev.9b00207

• Structural and conformational determinants of macrocycle cell permeability

  Nature Chemical Biology · 2016 · 10.1038/nchembio.2203

• Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

  Nature Communications · 2014 · 10.1038/ncomms4521

• Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

  Chemical Reviews · 2014 · 10.1021/cr400401e

• Conus Venom Peptide Pharmacology

  Pharmacological Reviews · 2012 · 10.1124/pr.111.005322

• Deep Venomics Reveals the Mechanism for Expanded Peptide Diversity in Cone Snail Venom

  Molecular & Cellular Proteomics · 2012 · 10.1074/mcp.m112.021469

• Role of voltage-gated calcium channels in ascending pain pathways

  Brain Research Reviews · 2009 · 10.1016/j.brainresrev.2008.12.021

• The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

  Annual Review of Genomics and Human Genetics · 2009 · https://doi.org/10.1146/annurev.genom.9.081307.164356

• Isolation and Characterization of a Cone Snail Protease with Homology to CRISP Proteins of the Pathogenesis-related Protein Superfamily

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m304843200

• Therapeutic potential of venom peptides

  Nature Reviews Drug Discovery · 2003 · https://doi.org/10.1038/nrd1197

• Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter

  Nature Neuroscience · 2001 · 10.1038/nn0901-902

• The changing face of ciguatera

  Toxicon · 2001 · 10.1016/s0041-0101(00)00161-6

• Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.m002252200

• Ciguatera: recent advances but the risk remains

  International Journal of Food Microbiology · 2000 · 10.1016/s0168-1605(00)00382-2

• Assessment of the role of α 2 ‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice

  British Journal of Pharmacology · 1997 · 10.1038/sj.bjp.0701520

• The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography.

  The EMBO Journal · 1996 · 10.1002/j.1460-2075.1996.tb00483.x

• Detection of Sodium Channel Toxins: Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seafood Extracts

  Journal of AOAC International · 1995 · 10.1093/jaoac/78.2.521

• Structure of a major immunogenic site on foot-and-mouth disease virus

  Nature · 1993 · 10.1038/362566a0

• Origin and transfer of toxins involved in ciguatera

  Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · 1993 · 10.1016/0742-8413(93)90217-9

• Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Muraenidae)

  Toxicon · 1991 · 10.1016/0041-0101(91)90209-a

• Registry of Toxic Effects of Chemical Substances

  Medical Entomology and Zoology · 1986

• Ciguatera in Australia: Occurrence, clinical features, pathophysiology and management

  The Medical Journal of Australia · 1986 · 10.5694/j.1326-5377.1986.tb139504.x

• Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

  Journal of Clinical Investigation · 1974 · 10.1172/jci107711

• Dangerous properties of industrial materials

  Food and Cosmetics Toxicology · 1969 · https://doi.org/10.1016/s0015-6264(69)80328-7

Current projects

No projects listed.