Reinhard Hohlfeld

Research interests

Publications

• Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

  Cell · 2022 · 10.1016/j.cell.2022.08.021

• Role of B Cells in Multiple Sclerosis and Related Disorders

  Annals of Neurology · 2020 · 10.1002/ana.25927

• Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

  The Lancet Neurology · 2018 · 10.1016/s1474-4422(18)30069-3

• Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

  Proceedings of the National Academy of Sciences · 2017 · https://doi.org/10.1073/pnas.1711233114

• Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society

  Journal of Neurology · 2016 · 10.1007/s00415-016-8045-z

• γ-secretase directly sheds the survival receptor BCMA from plasma cells

  Nature Communications · 2015 · 10.1038/ncomms8333

• Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis

  Neurology · 2011 · 10.1212/wnl.0b013e318228c0b1

• Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab

  Neurology · 2011 · 10.1212/wnl.0b013e3182152881

• A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

  New England Journal of Medicine · 2010 · https://doi.org/10.1056/nejmoa0909494

• MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

  Brain · 2009 · https://doi.org/10.1093/brain/awp300

• Mechanisms of Disease: aquaporin-4 antibodies in neuromyelitis optica

  Nature Clinical Practice Neurology · 2008 · 10.1038/ncpneuro0764

• Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis

  Nature Medicine · 2008 · 10.1038/nm1714

• Neurofascin as a novel target for autoantibody-mediated axonal injury

  The Journal of Experimental Medicine · 2007 · 10.1084/jem.20071053

• B lineage cells in the inflammatory central nervous system environment: Migration, maintenance, local antibody production, and therapeutic modulation

  Annals of Neurology · 2006 · 10.1002/ana.20890

• BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma

  The Journal of Experimental Medicine · 2005 · https://doi.org/10.1084/jem.20041674

• Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment

  Brain · 2005 · 10.1093/brain/awh680

• Multiple sclerosis: Brain-infiltrating CD8 + T cells persist as clonal expansions in the cerebrospinal fluid and blood

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0308689100

• Polymyositis and dermatomyositis

  The Lancet · 2003 · https://doi.org/10.1016/s0140-6736(03)14368-1

• BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?

  Brain · 2002 · 10.1093/brain/awf015

• Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

  The Journal of Experimental Medicine · 2000 · 10.1084/jem.192.3.393

• Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.97.13.7452

• Multiple sclerosis

  Neurology · 1999 · 10.1212/wnl.53.8.1622

• Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

  The Journal of Experimental Medicine · 1999 · 10.1084/jem.189.5.865

• Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives

  Brain · 1997 · 10.1093/brain/120.5.865

• Polymyositis and Dermatomyositis

  Neurocritical Care · 1994 · 10.1007/978-3-642-87602-8_72

Current projects

No projects listed.