Y. Eugene Chen

Research interests

Publications

• A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study

  European Heart Journal · 2022 · https://doi.org/10.1093/eurheartj/ehac093

• Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

  European Heart Journal · 2021 · 10.1093/eurheartj/ehab605

• Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

  Science Translational Medicine · 2020 · https://doi.org/10.1126/scitranslmed.aaz2841

• Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping

  Journal of Hepatology · 2020 · 10.1016/j.jhep.2020.03.006

• Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta

  Cardiovascular Research · 2020 · 10.1093/cvr/cvaa214

• Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb

  Stem Cell Research & Therapy · 2020 · 10.1186/s13287-020-01669-9

• TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice

  Gastroenterology · 2020 · 10.1053/j.gastro.2020.02.033

• Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis

  Circulation Research · 2018 · 10.1161/circresaha.118.312672

• Krüppel-like factors and vascular wall homeostasis

  Journal of Molecular Cell Biology · 2017 · 10.1093/jmcb/mjx037

• Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve

  Nature Communications · 2017 · 10.1038/ncomms15481

• TFEB inhibits endothelial cell inflammation and reduces atherosclerosis

  Science Signaling · 2017 · 10.1126/scisignal.aah4214

• RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms10548

• Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

  Stem Cells Translational Medicine · 2016 · 10.5966/sctm.2015-0177

• High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles

  ACS Nano · 2016 · https://doi.org/10.1021/acsnano.5b07522

• Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine

  Pharmacology & Therapeutics · 2014 · https://doi.org/10.1016/j.pharmthera.2014.09.009

• Effective gene targeting in rabbits using RNA-guided Cas9 nucleases

  Journal of Molecular Cell Biology · 2014 · 10.1093/jmcb/mjt047

• Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

  The American Journal of Human Genetics · 2014 · https://doi.org/10.1016/j.ajhg.2014.01.010

• MicroRNA-27 (miR-27) Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells

  Journal of Biological Chemistry · 2013 · 10.1074/jbc.m113.514372

• Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors

  Journal of Biological Chemistry · 2011 · 10.1074/jbc.m111.294785

• The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis

  The EMBO Journal · 2011 · https://doi.org/10.1038/emboj.2011.52

• Molecular recognition of nitrated fatty acids by PPARγ

  Nature Structural & Molecular Biology · 2008 · 10.1038/nsmb.1447

Current projects

No projects listed.