Douglas Hanahan

Research interests

Publications

• Embracing cancer complexity: Hallmarks of systemic disease

  Cell · 2024 · https://doi.org/10.1016/j.cell.2024.02.009

• Synaptic proximity enables NMDAR signalling to promote brain metastasis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1576-6

• The consensus molecular subtypes of colorectal cancer

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3967

• A colorectal cancer classification system that associates cellular phenotype and responses to therapy

  Nature Medicine · 2013 · https://doi.org/10.1038/nm.3175

• Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

  Cancer Cell · 2012 · https://doi.org/10.1016/j.ccr.2012.02.022

• Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

  Nature Medicine · 2011 · 10.1038/nm.2344

• Hallmarks of Cancer: The Next Generation

  Cell · 2011 · https://doi.org/10.1016/j.cell.2011.02.013

• Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

  Cancer Cell · 2010 · 10.1016/j.ccr.2009.12.041

• Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

  Cancer Cell · 2009 · 10.1016/j.ccr.2009.10.013

• Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

  Cancer Cell · 2009 · 10.1016/j.ccr.2009.01.027

• Modes of resistance to anti-angiogenic therapy

  Nature reviews. Cancer · 2008 · 10.1038/nrc2442

• Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

  Cancer Cell · 2005 · 10.1016/j.ccr.2005.09.005

• Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

  Journal of Clinical Investigation · 2003 · 10.1172/jci17929

• Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

  Journal of Clinical Investigation · 2003 · 10.1172/jci200317929

• MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

  Cell · 2000 · 10.1016/s0092-8674(00)00139-2

• Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

  Nature Cell Biology · 2000 · 10.1038/35036374

• The Hallmarks of Cancer

  Cell · 2000 · https://doi.org/10.1016/s0092-8674(00)81683-9

• Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

  Genes & Development · 1999 · 10.1101/gad.13.11.1382

• Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

  Science · 1999 · 10.1126/science.284.5415.808

• MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

  Cell · 1998 · 10.1016/s0092-8674(00)81169-1

• Signaling Vascular Morphogenesis and Maintenance

  Science · 1997 · 10.1126/science.277.5322.48

• Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

  Cell · 1996 · https://doi.org/10.1016/s0092-8674(00)80108-7

• Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.

  Proceedings of the National Academy of Sciences · 1990 · 10.1073/pnas.87.12.4645

• Induction of angiogenesis during the transition from hyperplasia to neoplasia

  Nature · 1989 · 10.1038/339058a0

• Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

  Nature · 1985 · 10.1038/315115a0

• Studies on transformation of Escherichia coli with plasmids

  Journal of Molecular Biology · 1983 · https://doi.org/10.1016/s0022-2836(83)80284-8

• Plasmid screening at high colony density

  Gene · 1980 · 10.1016/0378-1119(80)90144-4

Current projects

No projects listed.