George Coukos

Research interests

Publications

• Interpretation of T cell states from single-cell transcriptomics data using reference atlases

  Nature Communications · 2021 · 10.1038/s41467-021-23324-4

• Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

  Journal for ImmunoTherapy of Cancer · 2020 · https://doi.org/10.1136/jitc-2019-000337

• Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.09.015

• Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

  Nature Immunology · 2020 · 10.1038/s41590-020-0793-3

• Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

  Cancer Cell · 2019 · 10.1016/j.ccell.2019.05.004

• Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

  Nature Reviews Clinical Oncology · 2019 · https://doi.org/10.1038/s41571-019-0218-0

• Consensus guidelines for the use and interpretation of angiogenesis assays

  Angiogenesis · 2018 · 10.1007/s10456-018-9613-x

• Interrogating open issues in cancer precision medicine with patient-derived xenografts

  Nature reviews. Cancer · 2017 · https://doi.org/10.1038/nrc.2016.140

• Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

  Nature reviews. Cancer · 2015 · https://doi.org/10.1038/nrc4019

• Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers

  Cancer Cell · 2015 · 10.1016/j.ccell.2015.09.006

• Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

  Nature Medicine · 2014 · 10.1038/nm.3541

• Deciphering and Reversing Tumor Immune Suppression

  Immunity · 2013 · 10.1016/j.immuni.2013.07.005

• Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

  Cancer Research · 2013 · 10.1158/0008-5472.can-12-4100

• T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

  Cancer Research · 2012 · 10.1158/0008-5472.can-11-3687

• Cancer immunotherapy comes of age

  Nature · 2011 · https://doi.org/10.1038/nature10673

• Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

  Gynecologic Oncology · 2011 · 10.1016/j.ygyno.2011.09.039

• Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

  Nature · 2011 · 10.1038/nature10169

• Rethinking ovarian cancer: recommendations for improving outcomes

  Nature reviews. Cancer · 2011 · https://doi.org/10.1038/nrc3144

• Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

  Blood · 2009 · 10.1182/blood-2009-03-208249

• Modulation of the antitumor immune response by complement

  Nature Immunology · 2008 · 10.1038/ni.1655

• The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

  Nature Cell Biology · 2008 · 10.1038/ncb1681

• Laser-capture microdissection

  Nature Protocols · 2006 · 10.1038/nprot.2006.85

• microRNAs exhibit high frequency genomic alterations in human cancer

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0508889103

• Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

  Nature Medicine · 2004 · https://doi.org/10.1038/nm1093

• Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

  New England Journal of Medicine · 2003 · https://doi.org/10.1056/nejmoa020177

• Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

  PubMed · 2001

Current projects

No projects listed.