G. Steven Bova

Research interests

Publications

• Mutational signatures of ionizing radiation in second malignancies

  Nature Communications · 2016 · 10.1038/ncomms12605

• The evolutionary history of lethal metastatic prostate cancer

  Nature · 2015 · https://doi.org/10.1038/nature14347

• Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

  Science · 2014 · 10.1126/science.1251343

• Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

  eLife · 2014 · 10.7554/elife.02935

• Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

  Molecular Cancer Therapeutics · 2010 · 10.1158/1535-7163.mct-09-0589

• Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

  Nature Genetics · 2010 · 10.1038/ng.613

• Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

  Nature Medicine · 2009 · 10.1038/nm.1944

• Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

  Cancer Research · 2008 · https://doi.org/10.1158/0008-5472.can-08-2764

• DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity

  Cancer Research · 2008 · 10.1158/0008-5472.can-07-6088

• Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer

  Cancer Research · 2004 · 10.1158/0008-5472.can-03-3972

• Hedgehog signalling in prostate regeneration, neoplasia and metastasis

  Nature · 2004 · https://doi.org/10.1038/nature02962

• Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

  Nature Genetics · 2002 · 10.1038/ng994

• Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers

  American Journal Of Pathology · 1999 · 10.1016/s0002-9440(10)65440-5

• Evidence for a prostate cancer susceptibility locus on the X chromosome.

  Nature Genetics · 1998 · https://doi.org/10.1038/2477

• Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

  PubMed · 1998

• Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

  PubMed · 1997

• DPC4 gene in various tumor types.

  PubMed · 1996

• Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

  Science · 1996 · https://doi.org/10.1126/science.274.5291.1371

• Telomerase activity: a prevalent marker of malignant human prostate tissue.

  PubMed · 1996

• Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping.

  PubMed · 1996

• Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer.

  PubMed · 1996

• Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

  Nature Genetics · 1995 · 10.1038/ng1095-210

• Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

  Proceedings of the National Academy of Sciences · 1994 · 10.1073/pnas.91.24.11733

• Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer.

  PubMed · 1993

• Hereditary Prostate Cancer: Epidemiologic and Clinical Features

  The Journal of Urology · 1993 · 10.1016/s0022-5347(17)35617-3

Current projects

No projects listed.