Thomas M. Coffman

Research interests

Publications

• Pathophysiology of Hypertension

  Circulation Research · 2021 · https://doi.org/10.1161/circresaha.121.318082

• Animal Models of Hypertension: A Scientific Statement From the American Heart Association

  Hypertension · 2019 · https://doi.org/10.1161/hyp.0000000000000090

• Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

  Physiological Reviews · 2018 · https://doi.org/10.1152/physrev.00038.2017

• In the Wake of Systolic Blood Pressure Intervention Trial: New Targets for Improving Hypertension Management in Chronic Kidney Disease?

  ˜The œNephron journals/Nephron journals · 2017 · https://doi.org/10.1159/000455130

• Classical Renin‐Angiotensin System in Kidney Physiology

  Comprehensive physiology · 2014 · https://doi.org/10.1002/cphy.c130040

• Under pressure: the search for the essential mechanisms of hypertension

  Nature Medicine · 2011 · https://doi.org/10.1038/nm.2541

• Mouse Models of Diabetic Nephropathy

  Journal of the American Society of Nephrology · 2009 · https://doi.org/10.1681/asn.2009070721

• Disruption of the Ang II type 1 receptor promotes longevity in mice

  Journal of Clinical Investigation · 2009 · https://doi.org/10.1172/jci36703

• Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice

  Journal of Clinical Investigation · 2006 · https://doi.org/10.1172/jci16980

• Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0605545103

• ACE and ACE2 Activity in Diabetic Mice

  Diabetes · 2006 · https://doi.org/10.2337/db06-0033

• Impact of genetic background on nephropathy in diabetic mice

  American Journal of Physiology-Renal Physiology · 2005 · https://doi.org/10.1152/ajprenal.00204.2005

• Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

  Journal of Clinical Investigation · 2005 · https://doi.org/10.1172/jci23378

• Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2

  Science · 2002 · https://doi.org/10.1126/science.1068711

• Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

  Journal of Clinical Investigation · 2001 · https://doi.org/10.1172/jci200113416

• Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse

  Journal of Clinical Investigation · 2001 · https://doi.org/10.1172/jci13640

• Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice

  Nature Medicine · 1999 · https://doi.org/10.1038/13522

• Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway

  Journal of Clinical Investigation · 1999 · https://doi.org/10.1172/jci7451

• Reduced growth, abnormal kidney structure, and type 2 (AT 2 ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT 1A and AT 1B receptors for angiotensin II

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.26.15496

• The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth

  Nature · 1997 · https://doi.org/10.1038/36342

• Genetic control of blood pressure and the angiotensinogen locus.

  Proceedings of the National Academy of Sciences · 1995 · https://doi.org/10.1073/pnas.92.7.2735

• Regulation of blood pressure by the type 1A angiotensin II receptor gene.

  Proceedings of the National Academy of Sciences · 1995 · https://doi.org/10.1073/pnas.92.8.3521

• Requirement of Mip-1α for an Inflammatory Response to Viral Infection

  Science · 1995 · https://doi.org/10.1126/science.7667639

Current projects

No projects listed.