Hendrik G. Stunnenberg

Research interests

Publications

• BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

  Cell Host & Microbe · 2018 · https://doi.org/10.1016/j.chom.2017.12.010

• The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0028-4

• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4292

• The interplay of epigenetic marks during stem cell differentiation and development

  Nature Reviews Genetics · 2017 · 10.1038/nrg.2017.57

• N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

  Nature Structural & Molecular Biology · 2017 · https://doi.org/10.1038/nsmb.3462

• β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

  Cell · 2016 · 10.1016/j.cell.2016.09.034

• Trained immunity: A program of innate immune memory in health and disease

  Science · 2016 · https://doi.org/10.1126/science.aaf1098

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · https://doi.org/10.1038/nature17676

• Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.10.026

• Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

  Cell · 2016 · 10.1016/j.cell.2016.09.037

• Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.10.008

• The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.10.042

• The topography of mutational processes in breast cancer genomes

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms11383

• Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

  Immunity · 2016 · 10.1016/j.immuni.2016.10.021

• Whole-genome fingerprint of the DNA methylome during human B cell differentiation

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3291

• Non-coding recurrent mutations in chronic lymphocytic leukaemia

  Nature · 2015 · 10.1038/nature14666

• Transcriptional diversity during lineage commitment of human blood progenitors

  Science · 2014 · https://doi.org/10.1126/science.1251033

• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  Science · 2014 · https://doi.org/10.1126/science.1250684

• Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

  Science · 2014 · https://doi.org/10.1126/science.1251086

• Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

  Nature Neuroscience · 2013 · https://doi.org/10.1038/nn.3512

• The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

  Cell · 2012 · 10.1016/j.cell.2012.03.026

• Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1202870109

• Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

  Cell Host & Microbe · 2012 · 10.1016/j.chom.2012.06.006

• BLUEPRINT to decode the epigenetic signature written in blood

  Nature Biotechnology · 2012 · https://doi.org/10.1038/nbt.2153

• Molecular mechanism of anaerobic ammonium oxidation

  Nature · 2011 · 10.1038/nature10453

• Quantitative comparison of genome-wide DNA methylation mapping technologies

  Nature Biotechnology · 2010 · 10.1038/nbt.1681

• Genome‐wide analysis of ETS‐family DNA‐binding in vitro and in vivo

  The EMBO Journal · 2010 · https://doi.org/10.1038/emboj.2010.106

• An oestrogen-receptor-α-bound human chromatin interactome

  Nature · 2009 · https://doi.org/10.1038/nature08497

• Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

  Cell · 2008 · https://doi.org/10.1016/j.cell.2008.02.047

• Genome-wide profiling of PPARγ:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

  Genes & Development · 2008 · 10.1101/gad.501108

• Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry

  Nature · 2002 · 10.1038/nature01111

• Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle

  Nature · 1993 · 10.1038/362471a0

Current projects

No projects listed.