Willem A. Hanekom

Research interests

Publications

• SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape

  Cell Host & Microbe · 2022 · 10.1016/j.chom.2022.01.005

• Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03471-w

• Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

  Nature · 2021 · https://doi.org/10.1038/s41586-021-04387-1

• SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

  medRxiv · 2021 · 10.1101/2021.12.08.21267417

• Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

  New England Journal of Medicine · 2018 · https://doi.org/10.1056/nejmoa1714021

• A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

  Nature · 2018 · 10.1038/s41586-018-0439-x

• Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis

  American Journal of Respiratory and Critical Care Medicine · 2018 · 10.1164/rccm.201711-2340oc

• Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

  Cell Host & Microbe · 2017 · 10.1016/j.chom.2017.05.012

• Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

  PLoS Pathogens · 2017 · 10.1371/journal.ppat.1006687

• A blood RNA signature for tuberculosis disease risk: a prospective cohort study

  The Lancet · 2016 · https://doi.org/10.1016/s0140-6736(15)01316-1

• T-cell activation is an immune correlate of risk in BCG vaccinated infants

  Nature Communications · 2016 · 10.1038/ncomms11290

• T cells and adaptive immunity to Mycobacterium tuberculosis in humans

  Immunological Reviews · 2015 · 10.1111/imr.12274

• First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

  Vaccine · 2015 · 10.1016/j.vaccine.2015.06.051

• COMPASS identifies T-cell subsets correlated with clinical outcomes

  Nature Biotechnology · 2015 · 10.1038/nbt.3187

• Mycobacterium tuberculosis ‐specific CD8 + T cells are functionally and phenotypically different between latent infection and active disease

  European Journal of Immunology · 2013 · 10.1002/eji.201243262

• Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

  The Lancet · 2013 · https://doi.org/10.1016/s0140-6736(13)60177-4

• Dominant TNF-α+ Mycobacterium tuberculosis–specific CD4+ T cell responses discriminate between latent infection and active disease

  Nature Medicine · 2011 · 10.1038/nm.2299

• Functional Capacity of Mycobacterium tuberculosis-Specific T Cell Responses in Humans Is Associated with Mycobacterial Load

  The Journal of Immunology · 2011 · 10.4049/jimmunol.1101122

• Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

  Blood · 2011 · 10.1182/blood-2011-05-353789

• Immunological biomarkers of tuberculosis

  Nature reviews. Immunology · 2011 · 10.1038/nri2960

• The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults

  American Journal of Respiratory and Critical Care Medicine · 2010 · 10.1164/rccm.200910-1484oc

• Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guérin Vaccination of Newborns

  American Journal of Respiratory and Critical Care Medicine · 2010 · 10.1164/rccm.201003-0334oc

• Influence of BCG vaccine strain on the immune response and protection against tuberculosis

  FEMS Microbiology Reviews · 2008 · 10.1111/j.1574-6976.2008.00118.x

• Bacillus Calmette-Guerin Vaccination of Human Newborns Induces T Cells with Complex Cytokine and Phenotypic Profiles

  The Journal of Immunology · 2008 · 10.4049/jimmunol.180.5.3569

• Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response

  The Journal of Immunology · 2008 · 10.4049/jimmunol.180.3.1962

Current projects

No projects listed.