Keith R. Matthews

Research interests

Publications

• Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

  Cell · 2018 · 10.1016/j.cell.2018.10.041

• Drug resistance in eukaryotic microorganisms

  Nature Microbiology · 2016 · 10.1038/nmicrobiol.2016.92

• The within-host dynamics of African trypanosome infections

  Philosophical Transactions of the Royal Society B Biological Sciences · 2015 · 10.1098/rstb.2014.0288

• Transcriptome‐wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co‐transcriptional degradation in determining mRNA levels

  Molecular Microbiology · 2014 · 10.1111/mmi.12764

• Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei

  Frontiers in Cellular and Infection Microbiology · 2013 · 10.3389/fcimb.2013.00078

• Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

  Nature · 2013 · 10.1038/nature12864

• Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

  Antimicrobial Agents and Chemotherapy · 2013 · 10.1128/aac.00044-13

• Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act

  Nature Reviews Microbiology · 2012 · 10.1038/nrmicro2779

• Controlling and Coordinating Development in Vector-Transmitted Parasites

  Science · 2011 · 10.1126/science.1198077

• Transmission Stages Dominate Trypanosome Within-Host Dynamics during Chronic Infections

  Cell Host & Microbe · 2011 · 10.1016/j.chom.2011.03.013

• A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway

  Genes & Development · 2010 · 10.1101/gad.570310

• Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei

  BMC Genomics · 2009 · 10.1186/1471-2164-10-427

• Differential Trypanosome Surface Coat Regulation by a CCCH Protein That Co-Associates with procyclin mRNA cis-Elements

  PLoS Pathogens · 2009 · 10.1371/journal.ppat.1000317

• A surface transporter family conveys the trypanosome differentiation signal

  Nature · 2009 · 10.1038/nature07997

• The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains

  BMC Genomics · 2007 · 10.1186/1471-2164-8-434

• The cell biology of Trypanosoma brucei differentiation

  Current Opinion in Microbiology · 2007 · 10.1016/j.mib.2007.09.014

• Protein tyrosine phosphatase Tb PTP1: a molecular switch controlling life cycle differentiation in trypanosomes

  The Journal of Cell Biology · 2006 · 10.1083/jcb.200605090

• The Genome of the Kinetoplastid Parasite, Leishmania major

  Science · 2005 · https://doi.org/10.1126/science.1112680

• The developmental cell biology of Trypanosoma brucei

  Journal of Cell Science · 2005 · 10.1242/jcs.01649

• A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form

  The EMBO Journal · 2001 · 10.1093/emboj/20.23.6700

• Flagellar Morphogenesis: Protein Targeting and Assembly in the Paraflagellar Rod of Trypanosomes

  Molecular and Cellular Biology · 1999 · 10.1128/mcb.19.12.8191

• A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei

  Molecular and Biochemical Parasitology · 1996 · 10.1016/0166-6851(96)02598-4

• Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes.

  The Journal of Cell Biology · 1994 · 10.1083/jcb.125.5.1147

• A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes.

  Genes & Development · 1994 · 10.1101/gad.8.4.491

• Temporal order of RNA-processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcripts.

  Molecular and Cellular Biology · 1993 · 10.1128/mcb.13.1.720

Current projects

No projects listed.