Nina Thiessen

Research interests

Publications

• Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

  Nature Genetics · 2019 · 10.1038/s41588-019-0547-z

• Spatial heterogeneity in medulloblastoma

  Nature Genetics · 2017 · 10.1038/ng.3838

• Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers

  Gastroenterology · 2017 · 10.1053/j.gastro.2017.05.012

• Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.05.046

• Integrated genomic and molecular characterization of cervical cancer

  Nature · 2017 · https://doi.org/10.1038/nature21386

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22973

• Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer

  Clinical Cancer Research · 2017 · 10.1158/1078-0432.ccr-17-1941

• Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways

  Cancer Cell · 2016 · 10.1016/j.ccell.2016.02.009

• Divergent clonal selection dominates medulloblastoma at recurrence

  Nature · 2016 · 10.1038/nature16478

• Comprehensive molecular characterization of gastric adenocarcinoma

  Nature · 2014 · https://doi.org/10.1038/nature13480

• Characterization of HPV and host genome interactions in primary head and neck cancers

  Proceedings of the National Academy of Sciences · 2014 · 10.1073/pnas.1416074111

• The genetic landscape of high-risk neuroblastoma

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2529

• Comprehensive molecular characterization of clear cell renal cell carcinoma

  Nature · 2013 · https://doi.org/10.1038/nature12222

• Comprehensive genomic characterization of squamous cell lung cancers

  Nature · 2012 · https://doi.org/10.1038/nature11404

• Subgroup-specific structural variation across 1,000 medulloblastoma genomes

  Nature · 2012 · 10.1038/nature11327

• Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells

  Journal of Biological Chemistry · 2012 · 10.1074/jbc.m112.413047

• Identification and characterization of Hoxa9 binding sites in hematopoietic cells

  Blood · 2011 · 10.1182/blood-2011-03-341081

• Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers

  The Journal of Pathology · 2011 · 10.1002/path.2995

• SDHA Loss-of-Function Mutations in KIT-PDGFRA Wild-Type Gastrointestinal Stromal Tumors Identified by Massively Parallel Sequencing

  JNCI Journal of the National Cancer Institute · 2011 · 10.1093/jnci/djr130

• Conserved role of intragenic DNA methylation in regulating alternative promoters

  Nature · 2010 · https://doi.org/10.1038/nature09165

• Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors

  Genome biology · 2010 · 10.1186/gb-2010-11-8-r82

• De novo assembly and analysis of RNA-seq data

  Nature Methods · 2010 · 10.1038/nmeth.1517

• Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding

  Genome Research · 2008 · 10.1101/gr.078519.108

• Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing

  Nucleic Acids Research · 2008 · 10.1093/nar/gkn382

• Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

  Nature Methods · 2007 · 10.1038/nmeth1068

Current projects

No projects listed.