Keiran Raine

Research interests

Publications

• Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

  Cell · 2019 · 10.1016/j.cell.2019.02.012

• Prediction of acute myeloid leukaemia risk in healthy individuals

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0317-6

• Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

  Cell · 2018 · 10.1016/j.cell.2018.02.020

• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4292

• Genomic Evolution of Breast Cancer Metastasis and Relapse

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.07.005

• Universal Patterns of Selection in Cancer and Somatic Tissues

  Cell · 2017 · 10.1016/j.cell.2017.09.042

• Genomic Classification and Prognosis in Acute Myeloid Leukemia

  New England Journal of Medicine · 2016 · https://doi.org/10.1056/nejmoa1516192

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · https://doi.org/10.1038/nature17676

• Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

  Nature Genetics · 2015 · 10.1038/ng.3221

• Subclonal diversification of primary breast cancer revealed by multiregion sequencing

  Nature Medicine · 2015 · 10.1038/nm.3886

• Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

  Science · 2014 · 10.1126/science.1251343

• Clinical and biological implications of driver mutations in myelodysplastic syndromes

  Blood · 2013 · 10.1182/blood-2013-08-518886

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

  New England Journal of Medicine · 2013 · 10.1056/nejmoa1312542

• The Life History of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.023

• Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1113205

• Mutational Processes Molding the Genomes of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.024

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · 10.1038/nature11017

• Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

  Nature · 2011 · 10.1038/nature09639

• SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

  New England Journal of Medicine · 2011 · 10.1056/nejmoa1103283

• Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

  Nature · 2011 · 10.1038/nature10113

• Patterns of somatic mutation in human cancer genomes

  Nature · 2007 · https://doi.org/10.1038/nature05610

• Mutation analysis of 24 known cancer genes in the NCI-60 cell line set

  Molecular Cancer Therapeutics · 2006 · 10.1158/1535-7163.mct-06-0433

• Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-1855

• Intragenic ERBB2 kinase mutations in tumours

  Nature · 2004 · 10.1038/431525b

Current projects

No projects listed.