Michaël Pollak

Research interests

Publications

• mTOR as a central regulator of lifespan and aging

  F1000Research · 2019 · 10.12688/f1000research.17196.1

• mTOR coordinates protein synthesis, mitochondrial activity and proliferation

  Cell Cycle · 2015 · 10.4161/15384101.2014.991572

• Metformin: From Mechanisms of Action to Therapies

  Cell Metabolism · 2014 · https://doi.org/10.1016/j.cmet.2014.09.018

• Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

  Nature Medicine · 2014 · 10.1038/nm.3686

• Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

  Biochemical Journal · 2014 · 10.1042/bj20140620

• Metformin directly acts on mitochondria to alter cellular bioenergetics

  Cancer & Metabolism · 2014 · 10.1186/2049-3002-2-12

• mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

  Cell Metabolism · 2013 · https://doi.org/10.1016/j.cmet.2013.10.001

• Metformin improves healthspan and lifespan in mice

  Nature Communications · 2013 · https://doi.org/10.1038/ncomms3192

• Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK / NF ‐κ B activation

  Aging Cell · 2013 · 10.1111/acel.12075

• The insulin and insulin-like growth factor receptor family in neoplasia: an update

  Nature reviews. Cancer · 2012 · 10.1038/nrc3215

• Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

  Cancer Discovery · 2012 · 10.1158/2159-8290.cd-12-0263

• eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.1005320107

• Diabetes and Cancer

  Diabetes Care · 2010 · https://doi.org/10.2337/dc10-0666

• Diabetes and Cancer: A Consensus Report

  CA A Cancer Journal for Clinicians · 2010 · https://doi.org/10.3322/caac.20078

• The Type 1 Insulin-Like Growth Factor Receptor Pathway

  Clinical Cancer Research · 2008 · 10.1158/1078-0432.ccr-07-4879

• Insulin and insulin-like growth factor signalling in neoplasia

  Nature reviews. Cancer · 2008 · https://doi.org/10.1038/nrc2536

• Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-2310

• Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

  Cancer Research · 2006 · 10.1158/0008-5472.can-06-1500

• Insulin-like growth factors and neoplasia

  Nature reviews. Cancer · 2004 · 10.1038/nrc1387

• Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

  PubMed · 2002

• Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)

  JNCI Journal of the National Cancer Institute · 2001 · 10.1093/jnci/93.24.1852

• Anastrozole Is Superior to Tamoxifen as First-Line Therapy for Advanced Breast Cancer in Postmenopausal Women: Results of a North American Multicenter Randomized Trial

  Journal of Clinical Oncology · 2000 · 10.1200/jco.2000.18.22.3758

• Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

  JNCI Journal of the National Cancer Institute · 1999 · 10.1093/jnci/91.7.620

• Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

  Science · 1998 · https://doi.org/10.1126/science.279.5350.563

• Circulating concentrations of insulin-like growth factor I and risk of breast cancer

  The Lancet · 1998 · https://doi.org/10.1016/s0140-6736(97)10384-1

Current projects

No projects listed.