Johan Auwerx

Research interests

Publications

• Embracing cancer complexity: Hallmarks of systemic disease

  Cell · 2024 · https://doi.org/10.1016/j.cell.2024.02.009

• The gut microbiota influences skeletal muscle mass and function in mice

  Science Translational Medicine · 2019 · https://doi.org/10.1126/scitranslmed.aan5662

• Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

  The Journal of Cell Biology · 2017 · https://doi.org/10.1083/jcb.201702058

• Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

  Nature Medicine · 2016 · 10.1038/nm.4132

• NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

  Science · 2016 · https://doi.org/10.1126/science.aaf2693

• NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

  Cell Metabolism · 2015 · 10.1016/j.cmet.2015.05.023

• Mitonuclear protein imbalance as a conserved longevity mechanism

  Nature · 2013 · 10.1038/nature12188

• The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

  Cell · 2013 · 10.1016/j.cell.2013.06.016

• Sirtuins as regulators of metabolism and healthspan

  Nature Reviews Molecular Cell Biology · 2012 · https://doi.org/10.1038/nrm3293

• The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

  Cell Metabolism · 2012 · 10.1016/j.cmet.2012.04.022

• Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

  American Journal of Clinical Nutrition · 2011 · 10.3945/ajcn.110.001917

• Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

  Science · 2011 · 10.1126/science.1207861

• Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

  Cell Metabolism · 2011 · 10.1016/j.cmet.2011.10.002

• PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

  Current Opinion in Lipidology · 2009 · 10.1097/mol.0b013e328328d0a4

• AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

  Nature · 2009 · https://doi.org/10.1038/nature07813

• TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

  Cell Metabolism · 2009 · https://doi.org/10.1016/j.cmet.2009.08.001

• Targeting bile-acid signalling for metabolic diseases

  Nature Reviews Drug Discovery · 2008 · 10.1038/nrd2619

• Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.11.013

• Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

  Nature · 2006 · https://doi.org/10.1038/nature04330

• International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

  Pharmacological Reviews · 2006 · 10.1124/pr.58.4.5

• Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

  Nature · 2004 · 10.1038/nature02866

• Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

  Journal of Clinical Investigation · 2004 · 10.1172/jci21025

• Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

  Molecular Cell · 2000 · 10.1016/s1097-2765(00)00050-2

• A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

  Nature Genetics · 1998 · 10.1038/3099

• Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

  Circulation · 1998 · 10.1161/01.cir.98.19.2088

• Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients

  Diabetes · 1997 · 10.2337/diab.46.8.1319

• The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

  Journal of Biological Chemistry · 1997 · 10.1074/jbc.272.30.18779

• PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

  The EMBO Journal · 1996 · 10.1002/j.1460-2075.1996.tb00918.x

• The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

  Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1996 · 10.1016/0005-2760(96)00066-5

• Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

  Journal of Lipid Research · 1996 · 10.1016/s0022-2275(20)42003-6

• Transient increase in obese gene expression after food intake or insulin administration

  Nature · 1995 · 10.1038/377527a0

Current projects

No projects listed.