John Q. Trojanowski

Research interests

Publications

• Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14279-8

• Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

  Brain · 2019 · https://doi.org/10.1093/brain/awz099

• Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

  Alzheimer s & Dementia · 2018 · https://doi.org/10.1016/j.jalz.2018.07.217

• CSF biomarkers of Alzheimer's disease concord with amyloid‐β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts

  Alzheimer s & Dementia · 2018 · https://doi.org/10.1016/j.jalz.2018.01.010

• Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

  Brain · 2018 · https://doi.org/10.1093/brain/awy146

• Diagnosis and management of dementia with Lewy bodies

  Neurology · 2017 · https://doi.org/10.1212/wnl.0000000000004058

• Primary age-related tauopathy (PART): a common pathology associated with human aging

  Acta Neuropathologica · 2014 · 10.1007/s00401-014-1349-0

• Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

  The Lancet Neurology · 2013 · 10.1016/s1474-4422(12)70291-0

• The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

  Alzheimer s & Dementia · 2013 · 10.1016/j.jalz.2013.05.1769

• National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

  Alzheimer s & Dementia · 2012 · 10.1016/j.jalz.2011.10.007

• Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

  Journal of Clinical Investigation · 2012 · 10.1172/jci59903

• Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

  Journal of Neuropathology & Experimental Neurology · 2012 · 10.1097/nen.0b013e31825018f7

• Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

  Science · 2012 · 10.1126/science.1227157

• National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

  Acta Neuropathologica · 2011 · 10.1007/s00401-011-0910-3

• The Parkinson Progression Marker Initiative (PPMI)

  Progress in Neurobiology · 2011 · 10.1016/j.pneurobio.2011.09.005

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

  Nature Genetics · 2010 · 10.1038/ng.536

• Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

  The Lancet Neurology · 2009 · https://doi.org/10.1016/s1474-4422(09)70299-6

• Alzheimer's Disease Neuroimaging Initiative (ADNI)

  Neurology · 2009 · 10.1212/wnl.0b013e3181cb3e25

• Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

  Acta Neuropathologica · 2009 · 10.1007/s00401-009-0612-2

• Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

  Annals of Neurology · 2009 · 10.1002/ana.21610

• Second consensus statement on the diagnosis of multiple system atrophy

  Neurology · 2008 · 10.1212/01.wnl.0000324625.00404.15

• Alzheimer’s Disease Neuroimaging Initiative

  Advances in behavioral biology · 2007 · 10.1007/978-0-387-72076-0_18

• Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

  Neuron · 2007 · 10.1016/j.neuron.2007.01.010

• Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

  Acta Neuropathologica · 2007 · 10.1007/s00401-007-0237-2

• Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

  Nature reviews. Neuroscience · 2007 · 10.1038/nrn2194

• Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

  Science · 2006 · https://doi.org/10.1126/science.1134108

• Diagnosis and management of dementia with Lewy bodies

  Neurology · 2005 · https://doi.org/10.1212/01.wnl.0000187889.17253.b1

• The Alzheimer's Disease Neuroimaging Initiative

  Neuroimaging Clinics of North America · 2005 · 10.1016/j.nic.2005.09.008

• Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)

  Alzheimer s & Dementia · 2005 · 10.1016/j.jalz.2005.06.003

• Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease

  New England Journal of Medicine · 2001 · 10.1056/nejm200103083441002

• Neurodegenerative Tauopathies

  Annual Review of Neuroscience · 2001 · 10.1146/annurev.neuro.24.1.1121

• Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

  Science · 2000 · 10.1126/science.290.5493.985

• Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

  PubMed · 1998

• Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

  Nature · 1998 · 10.1038/31508

• Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

  Journal of Neuropathology & Experimental Neurology · 1997 · 10.1097/00005072-199710000-00002

• α-Synuclein in Lewy bodies

  Nature · 1997 · https://doi.org/10.1038/42166

Current projects

No projects listed.