Christine C. Winterbourn

Research interests

Publications

• Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

  Nature Metabolism · 2022 · https://doi.org/10.1038/s42255-022-00591-z

• Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

  Nature Reviews Molecular Cell Biology · 2022 · https://doi.org/10.1038/s41580-022-00456-z

• Reactive Oxygen Species and Neutrophil Function

  Annual Review of Biochemistry · 2016 · https://doi.org/10.1146/annurev-biochem-060815-014442

• Redox Reactions and Microbial Killing in the Neutrophil Phagosome

  Antioxidants and Redox Signaling · 2012 · https://doi.org/10.1089/ars.2012.4827

• Myeloperoxidase: a front-line defender against phagocytosed microorganisms

  Journal of Leukocyte Biology · 2012 · https://doi.org/10.1189/jlb.0712349

• Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

  Journal of Leukocyte Biology · 2012 · https://doi.org/10.1189/jlb.1211601

• Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

  Journal of Leukocyte Biology · 2011 · https://doi.org/10.1189/jlb.0711387

• Unraveling the Biological Roles of Reactive Oxygen Species

  Cell Metabolism · 2011 · https://doi.org/10.1016/j.cmet.2011.03.010

• Reconciling the chemistry and biology of reactive oxygen species

  Nature Chemical Biology · 2008 · https://doi.org/10.1038/nchembio.85

• Modeling the Reactions of Superoxide and Myeloperoxidase in the Neutrophil Phagosome

  Journal of Biological Chemistry · 2006 · https://doi.org/10.1074/jbc.m605898200

• Superoxide Converts Indigo Carmine to Isatin Sulfonic Acid

  Journal of Biological Chemistry · 2004 · https://doi.org/10.1074/jbc.m400334200

• Chlorination of Bacterial and Neutrophil Proteins during Phagocytosis and Killing of Staphylococcus aureus

  Journal of Biological Chemistry · 2002 · https://doi.org/10.1074/jbc.m106134200

• Myeloperoxidase

  Current Opinion in Hematology · 2000 · https://doi.org/10.1097/00062752-200001000-00010

• Biomarkers of myeloperoxidase-derived hypochlorous acid

  Free Radical Biology and Medicine · 2000 · https://doi.org/10.1016/s0891-5849(00)00204-5

• Nitrite as a Substrate and Inhibitor of Myeloperoxidase

  Journal of Biological Chemistry · 2000 · https://doi.org/10.1074/jbc.275.16.11638

• Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

  Blood · 1998 · https://doi.org/10.1182/blood.v92.9.3007.421k47_3007_3017

• Myeloperoxidase: a key regulator of neutrophil oxidant production

  Redox Report · 1997 · https://doi.org/10.1080/13510002.1997.11747085

• Thiocyanate and chloride as competing substrates for myeloperoxidase

  Biochemical Journal · 1997 · https://doi.org/10.1042/bj3270487

• Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide

  Biochemical Journal · 1997 · https://doi.org/10.1042/bj3210503

• Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils

  Infection and Immunity · 1996 · https://doi.org/10.1128/iai.64.9.3512-3517.1996

• Inhibition of myeloperoxidase by benzoic acid hydrazides

  Biochemical Journal · 1995 · https://doi.org/10.1042/bj3080559

• Chlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils

  Journal of Biological Chemistry · 1995 · https://doi.org/10.1074/jbc.270.28.16542

• Toxicity of iron and hydrogen peroxide: the Fenton reaction

  Toxicology Letters · 1995 · https://doi.org/10.1016/0378-4274(95)03532-x

• Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs

  Biochemical Pharmacology · 1991 · https://doi.org/10.1016/0006-2952(91)90565-m

• Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid

  Biochemical Journal · 1988 · https://doi.org/10.1042/bj2520529

Current projects

No projects listed.