Terho Lehtimäki

Research interests

Publications

• Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-021-00990-0

• Childhood Cardiovascular Risk Factors and Adult Cardiovascular Events

  New England Journal of Medicine · 2022 · https://doi.org/10.1056/nejmoa2109191

• Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01104-0

• Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

  Nature Human Behaviour · 2021 · https://doi.org/10.1038/s41562-021-01135-3

• Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00913-z

• Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

  Cell · 2020 · https://doi.org/10.1016/j.cell.2019.12.036

• Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.06.045

• The Polygenic and Monogenic Basis of Blood Traits and Diseases

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.008

• Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-10936-0

• Multi-ethnic genome-wide association study for atrial fibrillation

  Nature Genetics · 2018 · 10.1038/s41588-018-0133-9

• Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration

  Ophthalmology · 2018 · https://doi.org/10.1016/j.ophtha.2018.09.045

• Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04558-1

• Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0127-7

• Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

  bioRxiv (Cold Spring Harbor Laboratory) · 2018 · https://doi.org/10.1101/447367

• Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

  Nature Communications · 2018 · 10.1038/s41467-018-04951-w

• Association analyses based on false discovery rate implicate new loci for coronary artery disease

  Nature Genetics · 2017 · 10.1038/ng.3913

• Integrative approaches for large-scale transcriptome-wide association studies

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3506

• Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

  Nature Genetics · 2016 · 10.1038/ng.3598

• Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

  Human Molecular Genetics · 2015 · https://doi.org/10.1093/hmg/ddv472

• Metabolite Profiling and Cardiovascular Event Risk

  Circulation · 2015 · https://doi.org/10.1161/circulationaha.114.013116

• Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

  Molecular Psychiatry · 2014 · https://doi.org/10.1038/mp.2014.107

• Synaptic, transcriptional and chromatin genes disrupted in autism

  Nature · 2014 · https://doi.org/10.1038/nature13772

• Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

  American Journal of Clinical Nutrition · 2013 · https://doi.org/10.3945/ajcn.112.052183

• Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

  PLoS Medicine · 2013 · 10.1371/journal.pmed.1001383

• Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2554

• Adolescence Risk Factors Are Predictive of Coronary Artery Calcification at Middle Age

  Journal of the American College of Cardiology · 2012 · https://doi.org/10.1016/j.jacc.2012.05.045

• Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

  Nature Genetics · 2012 · 10.1038/ng.2500

• Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.922

• Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

  PLoS Medicine · 2011 · https://doi.org/10.1371/journal.pmed.1001116

• Microduplications of 16p11.2 are associated with schizophrenia

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.474

• Cohort Profile: The Cardiovascular Risk in Young Finns Study

  International Journal of Epidemiology · 2008 · https://doi.org/10.1093/ije/dym225

• Strong Association of De Novo Copy Number Mutations with Autism

  Science · 2007 · https://doi.org/10.1126/science.1138659

Current projects

No projects listed.