Thomas Metz

Research interests

Publications

• Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity

  Nature Microbiology · 2022 · https://doi.org/10.1038/s41564-022-01266-x

• BioTransformer 3.0—a web server for accurately predicting metabolic transformation products

  Nucleic Acids Research · 2022 · 10.1093/nar/gkac313

• Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation

  Nature Protocols · 2021 · https://doi.org/10.1038/s41596-021-00566-6

• Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

  Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2020 · https://doi.org/10.17615/dd92-mf79

• Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data

  Nature Biotechnology · 2020 · https://doi.org/10.1038/s41587-020-0700-3

• Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.05.004

• The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

  Nature Genetics · 2019 · 10.1038/s41588-019-0524-6

• MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

  Proceedings of the National Academy of Sciences · 2018 · https://doi.org/10.1073/pnas.1706928115

• Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease

  New England Journal of Medicine · 2018 · https://doi.org/10.1056/nejmoa1714458

• LIQUID: an-open source software for identifying lipids in LC-MS/MS-based lipidomics data

  Bioinformatics · 2017 · https://doi.org/10.1093/bioinformatics/btx046

• Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis

  Cell Host & Microbe · 2017 · https://doi.org/10.1016/j.chom.2017.10.011

• MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

  mSystems · 2016 · https://doi.org/10.1128/msystems.00043-16

• Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry

  The Analyst · 2016 · https://doi.org/10.1039/c5an02062j

• Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome

  Nature Microbiology · 2016 · https://doi.org/10.1038/nmicrobiol.2016.221

• Review, Evaluation, and Discussion of the Challenges of Missing Value Imputation for Mass Spectrometry-Based Label-Free Global Proteomics

  Journal of Proteome Research · 2015 · https://doi.org/10.1021/pr501138h

• Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

  mBio · 2014 · https://doi.org/10.1128/mbio.01174-14

• Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

  mBio · 2013 · 10.1128/mbio.00271-13

• Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells

  Journal of Virology · 2013 · https://doi.org/10.1128/jvi.02520-12

• Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells

  PLoS Pathogens · 2012 · https://doi.org/10.1371/journal.ppat.1002584

• Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

  Diabetes · 2012 · 10.2337/db11-1120

• Model‐driven multi‐omic data analysis elucidates metabolic immunomodulators of macrophage activation

  Molecular Systems Biology · 2012 · 10.1038/msb.2012.21

• Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

  PLoS Pathogens · 2010 · https://doi.org/10.1371/journal.ppat.1000719

• A statistical framework for protein quantitation in bottom-up MS-based proteomics

  Bioinformatics · 2009 · 10.1093/bioinformatics/btp362

• A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease

  Journal of Proteome Research · 2008 · https://doi.org/10.1021/pr800858h

• Enrichment and Analysis of Nonenzymatically Glycated Peptides: Boronate Affinity Chromatography Coupled with Electron-Transfer Dissociation Mass Spectrometry

  Journal of Proteome Research · 2007 · 10.1021/pr070112q

• Automated 20 kpsi RPLC-MS and MS/MS with Chromatographic Peak Capacities of 1000−1500 and Capabilities in Proteomics and Metabolomics

  Analytical Chemistry · 2005 · https://doi.org/10.1021/ac0483062

• Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications

  Archives of Biochemistry and Biophysics · 2003 · 10.1016/j.abb.2003.08.021

• A Post-Amadori Inhibitor Pyridoxamine Also Inhibits Chemical Modification of Proteins by Scavenging Carbonyl Intermediates of Carbohydrate and Lipid Degradation

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m109935200

Current projects

No projects listed.