Peter L. M. Jansen

Research interests

Publications

• The ascending pathophysiology of cholestatic liver disease

  Hepatology · 2016 · https://doi.org/10.1002/hep.28965

• New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

  Journal of Hepatology · 2015 · https://doi.org/10.1016/j.jhep.2015.02.023

• Bile acid receptors as targets for drug development

  Nature Reviews Gastroenterology & Hepatology · 2013 · https://doi.org/10.1038/nrgastro.2013.151

• Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma

  Journal of Hepatology · 2012 · https://doi.org/10.1016/j.jhep.2011.11.026

• The Biliary HCO3 − Umbrella: A Unifying Hypothesis on Pathogenetic and Therapeutic Aspects of Fibrosing Cholangiopathies

  Hepatology · 2010 · https://doi.org/10.1002/hep.23810

• High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis #

  Hepatology · 2008 · https://doi.org/10.1002/hep.22771

• Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C

  Hepatology · 2007 · https://doi.org/10.1002/hep.21774

• Rapid Decline of Viral RNA in Hepatitis C Patients Treated With VX-950: A Phase Ib, Placebo-Controlled, Randomized Study

  Gastroenterology · 2006 · https://doi.org/10.1053/j.gastro.2006.07.013

• Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: Involvement of JNK and ERK MAP kinases

  Journal of Hepatology · 2005 · https://doi.org/10.1016/j.jhep.2005.07.034

• Molecular Pathogenesis of Cholestasis

  Journal · 2004 · https://doi.org/10.1007/978-1-4419-9034-1

• Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways†

  Hepatology · 2004 · https://doi.org/10.1002/hep.20246

• Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11

  Gastroenterology · 2004 · https://doi.org/10.1053/j.gastro.2004.04.065

• Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

  Hepatology · 2002 · https://doi.org/10.1053/jhep.2002.31724

• Increased cancer risk after liver transplantation: a population-based study

  Journal of Hepatology · 2001 · https://doi.org/10.1016/s0168-8278(00)00077-5

• Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

  Gastroenterology · 1999 · https://doi.org/10.1016/s0016-5085(99)70287-8

• ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

  British Journal of Pharmacology · 1999 · https://doi.org/10.1038/sj.bjp.0702360

• Up–Regulation of the Multidrug Resistance Genes, Mrp1 And Mdr1b , and Down–Regulation of the Organic Anion Transporter, Mrp2, and the Bile Salt Transporter, Spgp, in Endotoxemic Rat Liver

  Hepatology · 1998 · https://doi.org/10.1002/hep.510280625

• Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

  Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · 1995 · https://doi.org/10.1016/0304-4157(95)00006-d

• The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome

  New England Journal of Medicine · 1995 · https://doi.org/10.1056/nejm199511023331802

• Hereditary Chronic Conjugated Hyperbilirubinemia in Mutant Rats Caused by Defective Hepatic Anion Transport

  Hepatology · 1985 · https://doi.org/10.1002/hep.1840050408

Current projects

No projects listed.