C.H. Arrowsmith

Research interests

Publications

• MYC protein interactors in gene transcription and cancer

  Nature reviews. Cancer · 2021 · 10.1038/s41568-021-00367-9

• Protein arginine methylation: from enigmatic functions to therapeutic targeting

  Nature Reviews Drug Discovery · 2021 · 10.1038/s41573-021-00159-8

• GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-18020-8

• Global analysis of protein folding using massively parallel design, synthesis, and testing

  Science · 2017 · 10.1126/science.aan0693

• WD40 repeat domain proteins: a novel target class?

  Nature Reviews Drug Discovery · 2017 · 10.1038/nrd.2017.179

• Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

  Nature · 2017 · https://doi.org/10.1038/nature23666

• Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

  Nature · 2015 · 10.1038/nature15251

• The promise and peril of chemical probes

  Nature Chemical Biology · 2015 · https://doi.org/10.1038/nchembio.1867

• Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

  Nature Medicine · 2015 · 10.1038/nm.3973

• Self-renewal as a therapeutic target in human colorectal cancer

  Nature Medicine · 2013 · 10.1038/nm.3418

• An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

  ACS Chemical Biology · 2013 · 10.1021/cb400133j

• Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

  Nature Structural & Molecular Biology · 2012 · 10.1038/nsmb.2391

• Epigenetic protein families: a new frontier for drug discovery

  Nature Reviews Drug Discovery · 2012 · https://doi.org/10.1038/nrd3674

• Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

  Cell · 2012 · https://doi.org/10.1016/j.cell.2012.02.013

• A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

  Nature Chemical Biology · 2011 · https://doi.org/10.1038/nchembio.599

• Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

  Blood · 2010 · 10.1182/blood-2010-11-321208

• Recognition and Specificity Determinants of the Human Cbx Chromodomains

  Journal of Biological Chemistry · 2010 · 10.1074/jbc.m110.191411

• Consistent blind protein structure generation from NMR chemical shift data

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0800256105

• Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

  Nature · 2008 · 10.1038/nature07273

• Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0605224103

• Molecular recognition of p53 and MDM2 by USP7/HAUSP

  Nature Structural & Molecular Biology · 2006 · 10.1038/nsmb1067

• Genome-wide Analysis of Substrate Specificities of the Escherichia coli Haloacid Dehalogenase-like Phosphatase Family

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m605449200

• Structure of the p53 Binding Domain of HAUSP/USP7 Bound to Epstein-Barr Nuclear Antigen 1

  Molecular Cell · 2005 · https://doi.org/10.1016/j.molcel.2005.02.029

• ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

  The EMBO Journal · 1997 · 10.1093/emboj/16.19.6018

• A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

  Journal of the American Chemical Society · 1994 · 10.1021/ja00105a005

Current projects

No projects listed.