Amy Sims

Research interests

Publications

• An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

  Science Translational Medicine · 2020 · https://doi.org/10.1126/scitranslmed.abb5883

• Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13940-6

• Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

  Antiviral Research · 2019 · https://doi.org/10.1016/j.antiviral.2019.104541

• Small-Molecule Antiviral β- d - N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

  Journal of Virology · 2019 · https://doi.org/10.1128/jvi.01348-19

• Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

  mBio · 2018 · https://doi.org/10.1128/mbio.00221-18

• MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

  Proceedings of the National Academy of Sciences · 2018 · https://doi.org/10.1073/pnas.1706928115

• Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aal3653

• MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

  mSystems · 2016 · https://doi.org/10.1128/msystems.00043-16

• Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

  Nature Biotechnology · 2016 · https://doi.org/10.1038/nbt.3597

• SARS-like WIV1-CoV poised for human emergence

  Proceedings of the National Academy of Sciences · 2016 · https://doi.org/10.1073/pnas.1517719113

• Human Coronavirus HKU1 Spike Protein Uses O -Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

  Journal of Virology · 2015 · https://doi.org/10.1128/jvi.00854-15

• Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

  mBio · 2014 · https://doi.org/10.1128/mbio.01174-14

• Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells

  Journal of Virology · 2013 · https://doi.org/10.1128/jvi.02520-12

• Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1311542110

• Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

  PLoS Pathogens · 2010 · https://doi.org/10.1371/journal.ppat.1001176

• Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0808116105

• Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

  PLoS Medicine · 2006 · https://doi.org/10.1371/journal.pmed.0030525

• Severe Acute Respiratory Syndrome Coronavirus Group-Specific Open Reading Frames Encode Nonessential Functions for Replication in Cell Cultures and Mice

  Journal of Virology · 2005 · https://doi.org/10.1128/jvi.79.23.14909-14922.2005

• The nsp2 Replicase Proteins of Murine Hepatitis Virus and Severe Acute Respiratory Syndrome Coronavirus Are Dispensable for Viral Replication

  Journal of Virology · 2005 · https://doi.org/10.1128/jvi.79.21.13399-13411.2005

• Severe Acute Respiratory Syndrome Coronavirus Infection of Human Ciliated Airway Epithelia: Role of Ciliated Cells in Viral Spread in the Conducting Airways of the Lungs

  Journal of Virology · 2005 · https://doi.org/10.1128/jvi.79.24.15511-15524.2005

Current projects

No projects listed.