Lee A. Denson

Research interests

Publications

• Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives

  Gastroenterology · 2023 · https://doi.org/10.1053/j.gastro.2023.05.032

• Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

  Nature Genetics · 2023 · https://doi.org/10.1038/s41588-023-01384-0

• Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis

  Gastroenterology · 2020 · 10.1053/j.gastro.2020.12.004

• Microbiota-derived metabolite promotes HDAC3 activity in the gut

  Nature · 2020 · 10.1038/s41586-020-2604-2

• Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease

  Gastroenterology · 2020 · https://doi.org/10.1053/j.gastro.2020.08.005

• Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease

  Gastroenterology · 2020 · https://doi.org/10.1053/j.gastro.2020.08.005

• Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.08.008

• Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course

  Cell Host & Microbe · 2018 · 10.1016/j.chom.2018.09.009

• Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

  Nature Communications · 2018 · 10.1038/s41467-018-07841-3

• Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease

  Nature Genetics · 2017 · 10.1038/ng.3936

• Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

  The Lancet · 2017 · 10.1016/s0140-6736(17)30317-3

• Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

  Nature Microbiology · 2017 · 10.1038/s41564-017-0089-z

• Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

  Nature Medicine · 2015 · 10.1038/nm.3933

• Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

  Journal of Clinical Investigation · 2014 · 10.1172/jci75436

• The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

  Cell Host & Microbe · 2014 · 10.1016/j.chom.2014.02.005

• Increased Effectiveness of Early Therapy With Anti-Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease

  Gastroenterology · 2013 · 10.1053/j.gastro.2013.10.027

• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.764

• ImproveCareNow: The development of a pediatric inflammatory bowel disease improvement network

  Inflammatory Bowel Diseases · 2010 · 10.1002/ibd.21394

• Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease

  The American Journal of Human Genetics · 2009 · https://doi.org/10.1016/j.ajhg.2009.01.026

• Common variants at five new loci associated with early-onset inflammatory bowel disease

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.489

• Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

  Nature Genetics · 2008 · 10.1038/ng.203

• GM-CSF Autoantibodies and Neutrophil Dysfunction in Pulmonary Alveolar Proteinosis

  New England Journal of Medicine · 2007 · 10.1056/nejmoa062505

• Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease

  Inflammatory Bowel Diseases · 2006 · 10.1097/00054725-200606000-00013

• The Orphan Nuclear Receptor, shp, Mediates Bile Acid-Induced Inhibition of the Rat Bile Acid Transporter, ntcp

  Gastroenterology · 2001 · 10.1053/gast.2001.25503

• Interleukin-1β Suppresses Retinoid Transactivation of Two Hepatic Transporter Genes Involved in Bile Formation

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.275.12.8835

Current projects

No projects listed.