Xinxin Ding

Research interests

Publications

• Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

  Acta Pharmaceutica Sinica B · 2022 · 10.1016/j.apsb.2022.03.009

• Reticulon proteins modulate autophagy of the endoplasmic reticulum in maize endosperm

  eLife · 2020 · 10.7554/elife.51918

• Autophagy Plays Prominent Roles in Amino Acid, Nucleotide, and Carbohydrate Metabolism during Fixed-Carbon Starvation in Maize

  The Plant Cell · 2020 · 10.1105/tpc.20.00226

• An update on the role of intestinal cytochrome P450 enzymes in drug disposition

  Acta Pharmaceutica Sinica B · 2016 · 10.1016/j.apsb.2016.07.012

• Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism

  · 2015 · 10.1002/9781118971758.ch3

• NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology

  Drug Metabolism and Disposition · 2012 · 10.1124/dmd.112.048991

• Preclinical experimental models of drug metabolism and disposition in drug discovery and development

  Acta Pharmaceutica Sinica B · 2012 · https://doi.org/10.1016/j.apsb.2012.10.004

• Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

  PLoS ONE · 2012 · 10.1371/journal.pone.0035206

• Generation and Characterization of a Cyp2f2-Null Mouse and Studies on the Role of CYP2F2 in Naphthalene-Induced Toxicity in the Lung and Nasal Olfactory Mucosa

  Journal of Pharmacology and Experimental Therapeutics · 2011 · 10.1124/jpet.111.184671

• Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

  Xenobiotica · 2011 · https://doi.org/10.3109/00498254.2011.618954

• Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model

  Journal of Pharmacology and Experimental Therapeutics · 2009 · 10.1124/jpet.109.162610

• Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems

  Journal of Biological Chemistry · 2008 · 10.1074/jbc.m802447200

• Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P 450 Reductase-Null Mice

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-1006

• In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa

  Molecular Pharmacology · 2004 · 10.1124/mol.104.007898

• METABOLISM OF NICOTINE AND COTININE BY HUMAN CYTOCHROME P450 2A13

  Drug Metabolism and Disposition · 2004 · 10.1124/dmd.104.002105

• Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts

  The Annual Review of Pharmacology and Toxicology · 2003 · https://doi.org/10.1146/annurev.pharmtox.43.100901.140251

• Liver-specific Deletion of the NADPH-Cytochrome P450 Reductase Gene

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m303125200

• Genetic Polymorphisms of the Human CYP2A13 Gene: Identification of Single-Nucleotide Polymorphisms and Functional Characterization of an Arg257Cys Variant

  Journal of Pharmacology and Experimental Therapeutics · 2002 · 10.1124/jpet.302.2.416

• CYP1B1 expression in human lung.

  PubMed · 2001

• Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

  PubMed · 2000

• Purification and Characterization of Heterologously Expressed Mouse CYP2A5 and CYP2G1: Role in Metabolic Activation of Acetaminophen and 2,6-Dichlorobenzonitrile in Mouse Olfactory Mucosal Microsomes

  Journal of Pharmacology and Experimental Therapeutics · 1998 · 10.1016/s0022-3565(24)37529-9

• Expression of CYP2A genes in rodent and human nasal mucosa.

  Drug Metabolism and Disposition · 1996 · 10.1016/s0090-9556(25)07449-5

• Cytochrome P450: progress and predictions

  The FASEB Journal · 1992 · https://doi.org/10.1096/fasebj.6.2.1537454

• Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue

  Neuroreport · 1992 · 10.1097/00001756-199209000-00007

• Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb.

  Molecular Pharmacology · 1990 · 10.1016/s0026-895x(25)10836-5

• Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes

  Biochemistry · 1988 · 10.1021/bi00422a007

Current projects

No projects listed.