F. von Delft

Research interests

Publications

• Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

  Proceedings of the National Academy of Sciences · 2023 · https://doi.org/10.1073/pnas.2212931120

• Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

  Science · 2023 · https://doi.org/10.1126/science.abo7201

• Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-25166-6

• Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

  Science Advances · 2021 · https://doi.org/10.1126/sciadv.abf8711

• Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-18709-w

• Crowdsourcing drug discovery for pandemics

  Nature Chemistry · 2020 · https://doi.org/10.1038/s41557-020-0496-2

• Targeting the Small GTPase Superfamily through Their Regulatory Proteins

  Angewandte Chemie International Edition · 2019 · https://doi.org/10.1002/anie.201900585

• Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

  Journal of the American Chemical Society · 2019 · https://doi.org/10.1021/jacs.9b02822

• CCP 4 i 2: the new graphical user interface to the CCP 4 program suite

  Acta Crystallographica Section D Structural Biology · 2018 · https://doi.org/10.1107/s2059798317016035

• An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

  eLife · 2018 · https://doi.org/10.7554/elife.36307

• A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms15123

• Gentle, fast and effective crystal soaking by acoustic dispensing

  Acta Crystallographica Section D Structural Biology · 2017 · https://doi.org/10.1107/s205979831700331x

• A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain

  Chemical Science · 2015 · https://doi.org/10.1039/c5sc03115j

• The Structural Basis of ZMPSTE24-Dependent Laminopathies

  Science · 2013 · https://doi.org/10.1126/science.1231513

• Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

  Journal of Biological Chemistry · 2013 · https://doi.org/10.1074/jbc.m112.437996

• Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1217042110

• Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

  Journal of Biological Chemistry · 2012 · https://doi.org/10.1074/jbc.m112.365932

• Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

  Journal of Medicinal Chemistry · 2012 · https://doi.org/10.1021/jm300677j

• Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

  Proceedings of the National Academy of Sciences · 2011 · https://doi.org/10.1073/pnas.1101262108

• Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases

  Journal of Biological Chemistry · 2011 · https://doi.org/10.1074/jbc.m110.206771

• The crystal structure of human GLRX5: iron–sulfur cluster co-ordination, tetrameric assembly and monomer activity

  Biochemical Journal · 2010 · https://doi.org/10.1042/bj20101286

• Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

  PLoS Biology · 2010 · https://doi.org/10.1371/journal.pbio.1000426

• Structural Snapshots for the Conformation-dependent Catalysis by Human Medium-chain Acyl-coenzyme A Synthetase ACSM2A

  Journal of Molecular Biology · 2009 · https://doi.org/10.1016/j.jmb.2009.03.064

• Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

  Nature · 2007 · https://doi.org/10.1038/nature05971

• Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

  Nature · 2000 · https://doi.org/10.1038/35039551

Current projects

No projects listed.