C. Bountra

Research interests

Publications

• A genetics-led approach defines the drug target landscape of 30 immune-related traits

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0456-1

• Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

  Cell chemical biology · 2017 · 10.1016/j.chembiol.2017.02.006

• Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

  Cancer Research · 2015 · https://doi.org/10.1158/0008-5472.can-15-0236

• Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

  Journal of Medicinal Chemistry · 2015 · 10.1021/acs.jmedchem.5b00209

• The promise and peril of chemical probes

  Nature Chemical Biology · 2015 · https://doi.org/10.1038/nchembio.1867

• EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial

  The Lancet · 2014 · https://doi.org/10.1016/s0140-6736(13)62337-5

• Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1217042110

• RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1310658110

• Epigenetic protein families: a new frontier for drug discovery

  Nature Reviews Drug Discovery · 2012 · https://doi.org/10.1038/nrd3674

• A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

  Nature · 2012 · https://doi.org/10.1038/nature11262

• Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

  Pain · 2008 · 10.1016/j.pain.2008.06.007

• Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

  BMC Neurology · 2007 · https://doi.org/10.1186/1471-2377-7-11

• Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score

  Journal of Clinical Neuroscience · 2007 · https://doi.org/10.1016/j.jocn.2006.09.002

• COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord

  BMC Neurology · 2006 · https://doi.org/10.1186/1471-2377-6-12

• An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients

  NeuroImage · 2006 · https://doi.org/10.1016/j.neuroimage.2006.03.024

• Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations

  BMC Urology · 2006 · 10.1186/1471-2490-6-6

• Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

  Pain · 2005 · https://doi.org/10.1016/j.pain.2005.01.002

• Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain

  BMC Women s Health · 2005 · 10.1186/1472-6874-5-2

• Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency

  The Lancet · 2003 · 10.1016/s0140-6736(03)12392-6

• Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states

  Pain · 2000 · https://doi.org/10.1016/s0304-3959(99)00251-1

• Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons

  Nature Neuroscience · 1998 · https://doi.org/10.1038/3652

• Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle.

  The Journal of Physiology · 1989 · 10.1113/jphysiol.1989.sp017833

Current projects

No projects listed.