Nathanael S. Gray

Research interests

Publications

• Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.07.020

• The dTAG system for immediate and target-specific protein degradation

  Nature Chemical Biology · 2018 · 10.1038/s41589-018-0021-8

• Plasticity in binding confers selectivity in ligand-induced protein degradation

  Nature Chemical Biology · 2018 · 10.1038/s41589-018-0055-y

• Kinase inhibitors: the road ahead

  Nature Reviews Drug Discovery · 2018 · 10.1038/nrd.2018.21

• CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0915

• YY1 Is a Structural Regulator of Enhancer-Promoter Loops

  Cell · 2017 · 10.1016/j.cell.2017.11.008

• A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

  Cell · 2017 · 10.1016/j.cell.2017.10.049

• A Landscape of Pharmacogenomic Interactions in Cancer

  Cell · 2016 · 10.1016/j.cell.2016.06.017

• Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

  Science Translational Medicine · 2016 · https://doi.org/10.1126/scitranslmed.aaf2304

• The promise and peril of chemical probes

  Nature Chemical Biology · 2015 · https://doi.org/10.1038/nchembio.1867

• Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

  Cell stem cell · 2014 · 10.1016/j.stem.2014.07.002

• CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

  Cell · 2014 · 10.1016/j.cell.2014.10.024

• Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

  ACS Chemical Biology · 2014 · https://doi.org/10.1021/cb500129t

• Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

  Nature · 2014 · 10.1038/nature13393

• Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

  Journal of Medicinal Chemistry · 2013 · https://doi.org/10.1021/jm400402q

• Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

  Chemistry & Biology · 2013 · 10.1016/j.chembiol.2012.12.006

• Systematic identification of genomic markers of drug sensitivity in cancer cells

  Nature · 2012 · https://doi.org/10.1038/nature11005

• A unifying model for mTORC1-mediated regulation of mRNA translation

  Nature · 2012 · 10.1038/nature11083

• Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

  Cancer Discovery · 2011 · https://doi.org/10.1158/2159-8274.cd-11-0005

• The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

  Science · 2011 · 10.1126/science.1199498

• The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers

  Cancer Research · 2010 · https://doi.org/10.1158/0008-5472.can-10-2956

• MEK1 mutations confer resistance to MEK and B-RAF inhibition

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0905833106

• An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

  Journal of Biological Chemistry · 2009 · 10.1074/jbc.m900301200

• DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

  Cell · 2009 · 10.1016/j.cell.2009.03.046

• Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

  Nature · 2009 · 10.1038/nature08622

• Activating mutations in ALK provide a therapeutic target in neuroblastoma

  Nature · 2008 · 10.1038/nature07397

• EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

  Clinical Cancer Research · 2008 · 10.1158/1078-0432.ccr-08-0168

• Targeting cancer with small molecule kinase inhibitors

  Nature reviews. Cancer · 2008 · 10.1038/nrc2559

• Rational design of inhibitors that bind to inactive kinase conformations

  Nature Chemical Biology · 2006 · 10.1038/nchembio799

• A chemical switch for inhibitor-sensitive alleles of any protein kinase

  Nature · 2000 · 10.1038/35030148

• Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

  Science · 1998 · 10.1126/science.281.5376.533

Current projects

No projects listed.