John Atack

Research interests

Publications

• Summary of Product Characteristics

  Journal · 2010 · https://doi.org/10.1007/978-3-540-68706-1_698

• Did Railroads Induce or Follow Economic Growth?: Urbanization and Population Growth in the American Midwest, 1850-1860

  Social Science History · 2010 · 10.1215/01455532-2009-024

• The complexity of the GABAA receptor shapes unique pharmacological profiles

  Drug Discovery Today · 2009 · 10.1016/j.drudis.2009.06.009

• R3(BΔ23–27)R/I5 Chimeric Peptide, a Selective Antagonist for GPCR135 and GPCR142 over Relaxin Receptor LGR7

  Journal of Biological Chemistry · 2007 · 10.1074/jbc.m701416200

• Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents

  Journal of Pharmacology and Experimental Therapeutics · 2007 · 10.1124/jpet.107.119404

• L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors

  Neuropharmacology · 2006 · 10.1016/j.neuropharm.2006.04.018

• An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

  Journal of Pharmacology and Experimental Therapeutics · 2006 · 10.1124/jpet.105.092320

• Different GABA A receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0405621102

• Evidence for a Significant Role of α3-Containing GABAAReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

  Journal of Neuroscience · 2005 · 10.1523/jneurosci.1166-05.2005

• TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

  Journal of Pharmacology and Experimental Therapeutics · 2005 · 10.1124/jpet.105.089920

• The benzodiazepine binding site of GABAAreceptors as a target for the development of novel anxiolytics

  Expert Opinion on Investigational Drugs · 2005 · 10.1517/13543784.14.5.601

• Sedation and Anesthesia Mediated by Distinct GABA A Receptor Isoforms

  Journal of Neuroscience · 2003 · 10.1523/jneurosci.23-24-08608.2003

• Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

  PubMed · 2003 · 10.1523/jneurosci.23-24-08608.2003

• Identification of a Novel, Selective GABAAα5 Receptor Inverse Agonist Which Enhances Cognition

  Journal of Medicinal Chemistry · 2003 · 10.1021/jm020582q

• Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA A Receptor

  Journal of Neuroscience · 2002 · https://doi.org/10.1523/jneurosci.22-13-05572.2002

• Loss of the Major GABA A Receptor Subtype in the Brain Is Not Lethal in Mice

  Journal of Neuroscience · 2001 · 10.1523/jneurosci.21-10-03409.2001

• Effect of α Subunit on Allosteric Modulation of Ion Channel Function in Stably Expressed Human Recombinant γ-Aminobutyric AcidAReceptors Determined Using36Cl Ion Flux

  Molecular Pharmacology · 2001 · 10.1124/mol.59.5.1108

• Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

  Nature Neuroscience · 2000 · https://doi.org/10.1038/75761

• Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain

  Brain Research · 1999 · 10.1016/s0006-8993(99)01152-x

• Preferential Coassembly of α4 and δ Subunits of the γ-Aminobutyric AcidAReceptor in Rat Thalamus

  Molecular Pharmacology · 1999 · 10.1124/mol.56.1.110

• Structure of inositol monophosphatase, the putative target of lithium therapy.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.21.10031

• Cerebrospinal fluid production is reduced in healthy aging

  Neurology · 1990 · https://doi.org/10.1212/wnl.40.3_part_1.500

• Reductions in [ 3 H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease

  Neurology · 1988 · 10.1212/wnl.38.5.720

• Molecular Forms of Acetylcholinesterase and Butyrylcholinesterase in the Aged Human Central Nervous System

  Journal of Neurochemistry · 1986 · 10.1111/j.1471-4159.1986.tb02858.x

• ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE

  The Lancet · 1986 · https://doi.org/10.1016/s0140-6736(86)92319-6

• Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

  Journal of Neurology Neurosurgery & Psychiatry · 1985 · https://doi.org/10.1136/jnnp.48.5.413

• Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: Selective loss of the intermediate (10S) form

  Neuroscience Letters · 1983 · 10.1016/0304-3940(83)90302-6

Current projects

No projects listed.