James M. Wilson

Research interests

Publications

• RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

  Nature · 2023 · https://doi.org/10.1038/s41586-023-05771-9

• Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

  Human Gene Therapy · 2018 · https://doi.org/10.1089/hum.2018.015

• A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

  Nature Biotechnology · 2016 · https://doi.org/10.1038/nbt.3469

• Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

  Human Gene Therapy · 2010 · https://doi.org/10.1089/hum.2010.055

• Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

  The Journal of Infectious Diseases · 2009 · https://doi.org/10.1086/595830

• Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0807027105

• Comparative Analysis of Adeno-Associated Viral Vector Serotypes 1, 2, 5, 7, And 8 in Mouse Brain

  Human Gene Therapy · 2007 · https://doi.org/10.1089/hum.2006.178

• Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

  Journal of Virology · 2004 · https://doi.org/10.1128/jvi.78.12.6381-6388.2004

• Postoperative atrial fibrillation and mortality after coronary artery bypass surgery

  Journal of the American College of Cardiology · 2004 · https://doi.org/10.1016/j.jacc.2003.11.023

• Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

  Molecular Genetics and Metabolism · 2003 · https://doi.org/10.1016/j.ymgme.2003.08.016

• Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

  Proceedings of the National Academy of Sciences · 2002 · https://doi.org/10.1073/pnas.182412299

• Natural Killer T Cell Ligand α-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines

  The Journal of Experimental Medicine · 2002 · https://doi.org/10.1084/jem.20011889

• Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver

  Molecular Therapy · 2001 · https://doi.org/10.1006/mthe.2000.0227

• Immune responses to adenovirus and adeno-associated virus in humans

  Gene Therapy · 1999 · https://doi.org/10.1038/sj.gt.3300994

• Gene Therapy Vectors Based on Adeno-Associated Virus Type 1

  Journal of Virology · 1999 · https://doi.org/10.1128/jvi.73.5.3994-4003.1999

• Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.

  Journal of Clinical Investigation · 1998 · https://doi.org/10.1172/jci2410

• The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.16.9541

• Recombinant adeno-associated virus for muscle directed gene therapy

  Nature Medicine · 1997 · https://doi.org/10.1038/nm0397-306

• Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

  Cell · 1997 · https://doi.org/10.1016/s0092-8674(00)81895-4

• Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

  Journal of Virology · 1996 · https://doi.org/10.1128/jvi.70.1.520-532.1996

• Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

  Journal of Virology · 1995 · https://doi.org/10.1128/jvi.69.4.2004-2015.1995

• A Controlled Study of Adenoviral-Vector–Mediated Gene Transfer in the Nasal Epithelium of Patients with Cystic Fibrosis

  New England Journal of Medicine · 1995 · https://doi.org/10.1056/nejm199509283331302

• Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

  Proceedings of the National Academy of Sciences · 1994 · https://doi.org/10.1073/pnas.91.10.4407

• MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

  Immunity · 1994 · https://doi.org/10.1016/1074-7613(94)90074-4

• Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

  Proceedings of the National Academy of Sciences · 1994 · https://doi.org/10.1073/pnas.91.13.6196

• Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

  Nature Genetics · 1994 · https://doi.org/10.1038/ng0494-335

• A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

  Nature Genetics · 1993 · https://doi.org/10.1038/ng0393-219

• Submucosal glands are the predominant site of CFTR expression in the human bronchus

  Nature Genetics · 1992 · https://doi.org/10.1038/ng1192-240

• Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

  Cell · 1990 · https://doi.org/10.1016/0092-8674(90)90398-x

Current projects

No projects listed.