Christopher J. Schofield

Research interests

Publications

• How formaldehyde reacts with amino acids

  Communications Chemistry · 2019 · https://doi.org/10.1038/s42004-019-0224-2

• 2-Oxoglutarate-Dependent Oxygenases

  Annual Review of Biochemistry · 2018 · 10.1146/annurev-biochem-061516-044724

• Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

  Chemical Science · 2017 · https://doi.org/10.1039/c7sc02103h

• A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

  Nature · 2012 · https://doi.org/10.1038/nature11262

• Methods for converting cysteine to dehydroalanine on peptides and proteins

  Chemical Science · 2011 · https://doi.org/10.1039/c1sc00185j

• The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

  EMBO Reports · 2011 · https://doi.org/10.1038/embor.2011.43

• Inhibition of 2-oxoglutarate dependent oxygenases

  Chemical Society Reviews · 2011 · 10.1039/c0cs00203h

• A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

  PLoS Genetics · 2009 · 10.1371/journal.pgen.1000599

• Classification, evolution, and species groups within the Triatominae

  Acta Tropica · 2009 · 10.1016/j.actatropica.2009.01.010

• Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

  Science · 2009 · 10.1126/science.1175865

• Phylogeography and Genetic Variation of Triatoma dimidiata, the Main Chagas Disease Vector in Central America, and Its Position within the Genus Triatoma

  PLoS neglected tropical diseases · 2008 · https://doi.org/10.1371/journal.pntd.0000233

• Expanding chemical biology of 2-oxoglutarate oxygenases

  Nature Chemical Biology · 2008 · 10.1038/nchembio0308-152

• Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

  Nature · 2007 · https://doi.org/10.1038/nature05971

• The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

  Science · 2007 · 10.1126/science.1151710

• Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0601283103

• Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins

  Journal of Inorganic Biochemistry · 2006 · 10.1016/j.jinorgbio.2006.01.024

• Signalling hypoxia by HIF hydroxylases

  Biochemical and Biophysical Research Communications · 2005 · 10.1016/j.bbrc.2005.08.111

• Oxygen sensing by HIF hydroxylases

  Nature Reviews Molecular Cell Biology · 2004 · 10.1038/nrm1366

• Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.c200644200

• Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

  Nature · 2002 · https://doi.org/10.1038/nature00767

• Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

  Biochemical Journal · 2002 · https://doi.org/10.1042/bj20021162

• Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.c200273200

• Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana

  Structure · 2002 · 10.1016/s0969-2126(01)00695-5

• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

  Science · 2001 · 10.1126/science.1059796

• C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

  Cell · 2001 · 10.1016/s0092-8674(01)00507-4

• Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

  Current Opinion in Structural Biology · 1999 · 10.1016/s0959-440x(99)00036-6

• Structure of a cephalosporin synthase

  Nature · 1998 · 10.1038/29575

• Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation

  Nature · 1997 · 10.1038/42990

• Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

  Nature · 1995 · 10.1038/375700a0

• UNDP/World Bank/WHO special programme for research and training in tropical diseases (TDR)

  Parasitology Today · 1989 · 10.1016/0169-4758(89)90254-8

Current projects

No projects listed.