Ian Tomlinson

Research interests

Publications

• Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

  Cancer Cell · 2023 · https://doi.org/10.1016/j.ccell.2023.08.002

• Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

  JAMA Oncology · 2022 · https://doi.org/10.1001/jamaoncol.2021.6744

• Pervasive chromosomal instability and karyotype order in tumour evolution

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2698-6

• Genetic predisposition to mosaic Y chromosome loss in blood

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1765-3

• An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

  Oncogenesis · 2019 · https://doi.org/10.1038/s41389-019-0125-3

• PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

  Journal of Medical Genetics · 2016 · https://doi.org/10.1136/jmedgenet-2016-103839

• Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CH EK 2 *1100delC Carriers

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2016.66.5844

• Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

  ˜The œLancet. Gastroenterology & hepatology · 2016 · https://doi.org/10.1016/s2468-1253(16)30014-0

• RAD51B in Familial Breast Cancer

  PLoS ONE · 2016 · https://doi.org/10.1371/journal.pone.0153788

• Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

  PLoS Medicine · 2016 · https://doi.org/10.1371/journal.pmed.1002105

• Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3304

• Identification of Novel Genetic Markers of Breast Cancer Survival

  JNCI Journal of the National Cancer Institute · 2015 · https://doi.org/10.1093/jnci/djv081

• MicroRNA Related Polymorphisms and Breast Cancer Risk

  PLoS ONE · 2014 · https://doi.org/10.1371/journal.pone.0109973

• Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms5999

• Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

  Nature Medicine · 2014 · https://doi.org/10.1038/nm.3750

• Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

  Cancer Research · 2014 · https://doi.org/10.1158/0008-5472.can-14-0013

• Large-scale genotyping identifies 41 new loci associated with breast cancer risk

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2563

• CCAT2 , a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

  Genome Research · 2013 · https://doi.org/10.1101/gr.152942.112

• Replication stress links structural and numerical cancer chromosomal instability

  Nature · 2013 · https://doi.org/10.1038/nature11935

• Genome-wide association studies identify four ER negative–specific breast cancer risk loci

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2561

• Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers

  The American Journal of Human Genetics · 2013 · https://doi.org/10.1016/j.ajhg.2013.01.002

• Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2503

• Genome-wide association analysis identifies three new breast cancer susceptibility loci

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.1049

• Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

  JNCI Journal of the National Cancer Institute · 2010 · https://doi.org/10.1093/jnci/djq526

• A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.668

• Common variants at 19p13 are associated with susceptibility to ovarian cancer

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.666

• A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.424

• The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.406

• Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

  Human Molecular Genetics · 2005 · https://doi.org/10.1093/hmg/ddi227

• Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

  Science · 1998 · https://doi.org/10.1126/science.280.5366.1086

• β-Catenin mutations in cell lines established from human colorectal cancers

  Proceedings of the National Academy of Sciences · 1997 · https://doi.org/10.1073/pnas.94.19.10330

Current projects

No projects listed.