Owen J. Sansom

Research interests

Publications

• Therapeutic targeting of tumour myeloid cells

  Nature reviews. Cancer · 2023 · https://doi.org/10.1038/s41568-022-00546-2

• Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

  Cancer Cell · 2023 · https://doi.org/10.1016/j.ccell.2023.08.002

• The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-020-00753-3

• Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

  Cancer Cell · 2019 · https://doi.org/10.1016/j.ccell.2019.08.003

• Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

  Science · 2018 · https://doi.org/10.1126/science.aao2774

• Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aai8504

• Genomic analyses identify molecular subtypes of pancreatic cancer

  Nature · 2016 · https://doi.org/10.1038/nature16965

• CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.04.014

• Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

  Stem Cell Reports · 2015 · https://doi.org/10.1016/j.stemcr.2015.03.003

• MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.03.006

• Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

  Nature Medicine · 2014 · https://doi.org/10.1038/nm.3750

• p53 status determines the role of autophagy in pancreatic tumour development

  Nature · 2013 · https://doi.org/10.1038/nature12865

• A complex secretory program orchestrated by the inflammasome controls paracrine senescence

  Nature Cell Biology · 2013 · https://doi.org/10.1038/ncb2784

• Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

  Journal of Clinical Investigation · 2012 · https://doi.org/10.1172/jci61067

• The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

  The EMBO Journal · 2012 · https://doi.org/10.1038/emboj.2012.166

• Crypt stem cells as the cells-of-origin of intestinal cancer

  Nature · 2008 · 10.1038/nature07602

Current projects

No projects listed.