Stafford L. Lightman

Research interests

Publications

• Dynamics of ACTH and Cortisol Secretion and Implications for Disease

  Endocrine Reviews · 2020 · 10.1210/endrev/bnaa002

• The human stress response

  Nature Reviews Endocrinology · 2019 · 10.1038/s41574-019-0228-0

• Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

  Stress · 2018 · 10.1080/10253890.2018.1470238

• The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis

  The Lancet Psychiatry · 2017 · 10.1016/s2215-0366(17)30328-0

• The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

  Endocrine Reviews · 2016 · 10.1210/er.2015-1080

• Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

  Molecular Cell · 2011 · https://doi.org/10.1016/j.molcel.2011.06.016

• The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration

  Nature reviews. Neuroscience · 2010 · 10.1038/nrn2914

• Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

  Nature Cell Biology · 2009 · 10.1038/ncb1922

• The HPA axis in major depression: classical theories and new developments

  Trends in Neurosciences · 2008 · https://doi.org/10.1016/j.tins.2008.06.006

• Interaction of the Glucocorticoid Receptor with the Chromatin Landscape

  Molecular Cell · 2008 · 10.1016/j.molcel.2008.02.010

• The Neuroendocrinology of Stress: A Never Ending Story

  Journal of Neuroendocrinology · 2008 · 10.1111/j.1365-2826.2008.01711.x

• Tryptophan metabolism in the central nervous system: medical implications

  Expert Reviews in Molecular Medicine · 2006 · https://doi.org/10.1017/s1462399406000068

• Do Corticosteroids Damage the Brain?

  Journal of Neuroendocrinology · 2006 · 10.1111/j.1365-2826.2006.01429.x

• Cortisol, Testosterone, and Coronary Heart Disease

  Circulation · 2005 · 10.1161/circulationaha.104.489088

• Syphilis and HIV: a dangerous combination

  The Lancet Infectious Diseases · 2004 · 10.1016/s1473-3099(04)01061-8

• Oxytocin Attenuates Stress-Induced c-fosmRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity

  Journal of Neuroscience · 2004 · 10.1523/jneurosci.3432-03.2004

• Cortisol pulsatility and its role in stress regulation and health

  Frontiers in Neuroendocrinology · 2004 · 10.1016/j.yfrne.2004.07.001

• Early-life exposure to endotoxin alters hypothalamic–pituitary–adrenal function and predisposition to inflammation

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.090571897

• Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination

  The Lancet · 1999 · 10.1016/s0140-6736(98)06098-x

• Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats1

  Endocrinology · 1997 · 10.1210/endo.138.7.5255

• Stress and the hypothalamo-pituitary-adrenal axis: acute, chronic and immunological activation

  Journal of Endocrinology · 1992 · 10.1677/joe.0.1340327

• Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat

  Journal of Endocrinology · 1989 · 10.1677/joe.0.1220705

• Vasopressin, oxytocin, dynorphin, enkephalin and corticotrophin‐releasing factor mRNA stimulation in the rat.

  The Journal of Physiology · 1987 · 10.1113/jphysiol.1987.sp016858

• Changes In Oxytocin and Vasopressin Secretion During Sexual Activity in Men

  The Journal of Clinical Endocrinology & Metabolism · 1987 · 10.1210/jcem-65-4-738

• Circadian Rhythms of Epinephrine and Norepinephrine in Man*

  The Journal of Clinical Endocrinology & Metabolism · 1985 · 10.1210/jcem-60-6-1210

Current projects

No projects listed.