Roger Williams

Research interests

Publications

• Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

  Science · 2013 · 10.1126/science.1243292

• Estimating Model-Adjusted Risks, Risk Differences, and Risk Ratios From Complex Survey Data

  American Journal of Epidemiology · 2010 · 10.1093/aje/kwp440

• Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

  Nature Chemical Biology · 2008 · 10.1038/nchembio.117

• A Role for the ESCRT System in Cell Division in Archaea

  Science · 2008 · 10.1126/science.1165322

• The emerging shape of the ESCRT machinery

  Nature Reviews Molecular Cell Biology · 2007 · 10.1038/nrm2162

• Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

  Science · 2007 · 10.1126/science.1135394

• A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.03.035

• Global challenges in liver disease

  Hepatology · 2006 · 10.1002/hep.21347

• Longitudinal Analysis of CD8+T Cells Specific for Structural and Nonstructural Hepatitis B Virus Proteins in Patients with Chronic Hepatitis B: Implications for Immunotherapy

  Journal of Virology · 2004 · 10.1128/jvi.78.11.5707-5719.2004

• FIP/AAPS guidelines to dissolution/in vitro release testing of novel/special dosage forms

  AAPS PharmSciTech · 2003 · 10.1208/pt040107

• Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

  Molecular Cell · 2000 · https://doi.org/10.1016/s1097-2765(05)00089-4

• The Role of Virus-Specific Cd8+ Cells in Liver Damage and Viral Control during Persistent Hepatitis B Virus Infection

  The Journal of Experimental Medicine · 2000 · https://doi.org/10.1084/jem.191.8.1269

• Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease

  New England Journal of Medicine · 2000 · https://doi.org/10.1056/nejm200006223422502

• The systemic inflammatory response syndrome in acute liver failure

  Hepatology · 2000 · 10.1053/jhep.2000.17687

• Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

  Cell · 2000 · 10.1016/s0092-8674(00)00196-3

• Structural insights into phosphoinositide 3-kinase catalysis and signalling

  Nature · 1999 · 10.1038/46319

• New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a

  Journal of Clinical Microbiology · 1997 · 10.1128/jcm.35.1.201-207.1997

• Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

  Nature · 1996 · 10.1038/380595a0

• Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British Society of Gastroenterology and the Royal College of Physicians of London.

  Gut · 1995 · 10.1136/gut.36.3.437

• Azathioprine for Long-Term Maintenance of Remission in Autoimmune Hepatitis

  New England Journal of Medicine · 1995 · 10.1056/nejm199510123331502

• Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

  Proceedings of the National Academy of Sciences · 1993 · https://doi.org/10.1073/pnas.90.13.6320

• Hepatitis B virus reinfection after orthotopic liver transplantation

  Journal of Hepatology · 1992 · 10.1016/0168-8278(92)90138-f

• Beneficial effect of azathioprine and prediction of prognosis in primary biliary cirrhosis

  Gastroenterology · 1985 · 10.1016/0016-5085(85)90213-6

• INFLUENCE OF DELTA INFECTION ON SEVERITY OF HEPATITIS B

  The Lancet · 1982 · 10.1016/s0140-6736(82)90156-8

• Hepatic pathology in relatives of patients with hæmochromatosis

  The Journal of Pathology and Bacteriology · 1962 · 10.1002/path.1700840107

Current projects

No projects listed.