Christine Klein

Research interests

Publications

• A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria

  The Lancet Neurology · 2024 · 10.1016/s1474-4422(23)00404-0

• Parkinson's disease

  The Lancet · 2021 · 10.1016/s0140-6736(21)00218-x

• Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects

  Journal of Parkinson s Disease · 2020 · 10.3233/jpd-201981

• LRRK2 in Parkinson disease: challenges of clinical trials

  Nature Reviews Neurology · 2020 · 10.1038/s41582-019-0301-2

• RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation

  Nature · 2018 · 10.1038/s41586-018-0448-9

• Genotype‐Phenotype Relations for the Parkinson's Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review

  Movement Disorders · 2018 · 10.1002/mds.27352

• Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

  Movement Disorders · 2017 · https://doi.org/10.1002/mds.27115

• N omenclature of genetic movement disorders: R ecommendations of the international P arkinson and movement disorder society task force

  Movement Disorders · 2016 · 10.1002/mds.26527

• PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

  Science · 2014 · 10.1126/science.1249161

• Lysosomal impairment in Parkinson's disease

  Movement Disorders · 2013 · 10.1002/mds.25462

• Phenomenology and classification of dystonia: A consensus update

  Movement Disorders · 2013 · https://doi.org/10.1002/mds.25475

• Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

  Nature Genetics · 2013 · 10.1038/ng.2723

• Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1112368109

• Genetics of Parkinson's Disease

  Cold Spring Harbor Perspectives in Medicine · 2012 · 10.1101/cshperspect.a008888

• Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

  PLoS Genetics · 2012 · 10.1371/journal.pgen.1002548

• Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

  Science Translational Medicine · 2012 · 10.1126/scitranslmed.3003985

• Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

  Journal of Neuroscience · 2011 · 10.1523/jneurosci.4441-10.2011

• Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

  The Lancet Neurology · 2011 · 10.1016/s1474-4422(11)70175-2

• Genome-wide association study reveals genetic risk underlying Parkinson's disease

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.487

• Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

  The Lancet Neurology · 2008 · https://doi.org/10.1016/s1474-4422(08)70117-0

• Deciphering the role of heterozygous mutations in genes associated with parkinsonism

  The Lancet Neurology · 2007 · 10.1016/s1474-4422(07)70174-6

• The phenotypic spectrum of rapid-onset dystonia-parkinsonism (RDP) and mutations in the ATP1A3 gene

  Brain · 2007 · 10.1093/brain/awl340

• LRRK2 G2019S as a Cause of Parkinson's Disease in Ashkenazi Jews

  New England Journal of Medicine · 2006 · 10.1056/nejmc055509

• A G Protein-coupled Receptor for UDP-glucose

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.275.15.10767

• The DYT1 phenotype and guidelines for diagnostic testing

  Neurology · 2000 · 10.1212/wnl.54.9.1746

Current projects

No projects listed.