Ian M. Adcock

Research interests

Publications

• IL-17–high asthma with features of a psoriasis immunophenotype

  Journal of Allergy and Clinical Immunology · 2019 · https://doi.org/10.1016/j.jaci.2019.03.027

• IL-17–high asthma with features of a psoriasis immunophenotype

  Journal of Allergy and Clinical Immunology · 2019 · https://doi.org/10.1016/j.jaci.2019.03.027

• Functional effects of the microbiota in chronic respiratory disease

  The Lancet Respiratory Medicine · 2019 · https://doi.org/10.1016/s2213-2600(18)30510-1

• Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

  European Respiratory Journal · 2019 · https://doi.org/10.1183/13993003.00588-2019

• Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

  Journal of Allergy and Clinical Immunology · 2018 · https://doi.org/10.1016/j.jaci.2018.05.026

• Update on Neutrophil Function in Severe Inflammation

  Frontiers in Immunology · 2018 · https://doi.org/10.3389/fimmu.2018.02171

• Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

  Journal of Allergy and Clinical Immunology · 2018 · https://doi.org/10.1016/j.jaci.2018.05.026

• U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

  Journal of Allergy and Clinical Immunology · 2016 · https://doi.org/10.1016/j.jaci.2016.08.048

• The relationship between COPD and lung cancer

  Lung Cancer · 2015 · https://doi.org/10.1016/j.lungcan.2015.08.017

• Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

  European Respiratory Journal · 2015 · https://doi.org/10.1183/13993003.00779-2015

• Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

  Journal of Allergy and Clinical Immunology · 2015 · https://doi.org/10.1016/j.jaci.2015.01.046

• Integrated care pathways for airway diseases (AIRWAYS-ICPs)

  European Respiratory Journal · 2014 · https://doi.org/10.1183/09031936.00014614

• International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

  European Respiratory Journal · 2013 · https://doi.org/10.1183/09031936.00202013

• Systems medicine and integrated care to combat chronic noncommunicable diseases

  Genome Medicine · 2011 · https://doi.org/10.1186/gm259

• Glucocorticoid resistance in inflammatory diseases

  The Lancet · 2009 · https://doi.org/10.1016/s0140-6736(09)60326-3

• Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

  European Respiratory Journal · 2008 · https://doi.org/10.1183/09031936.00018908

• Update on glucocorticoid action and resistance

  Journal of Allergy and Clinical Immunology · 2006 · https://doi.org/10.1016/j.jaci.2006.01.032

• Oxidative stress and redox regulation of lung inflammation in COPD

  European Respiratory Journal · 2006 · https://doi.org/10.1183/09031936.06.00053805

• Histone acetylation and deacetylation: importance in inflammatory lung diseases

  European Respiratory Journal · 2005 · https://doi.org/10.1183/09031936.05.00117504

• Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease

  New England Journal of Medicine · 2005 · https://doi.org/10.1056/nejmoa041892

• Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

  The Journal of Experimental Medicine · 2005 · https://doi.org/10.1084/jem.20050466

• Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase

  The Lancet · 2004 · https://doi.org/10.1016/s0140-6736(04)15650-x

• Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages

  The Journal of Experimental Medicine · 2004 · https://doi.org/10.1084/jem.20040416

• A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

  Proceedings of the National Academy of Sciences · 2002 · https://doi.org/10.1073/pnas.132556899

• p38 Mitogen-activated protein kinase–induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma

  Journal of Allergy and Clinical Immunology · 2002 · https://doi.org/10.1067/mai.2002.122465

• Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

  European Respiratory Journal · 2002 · https://doi.org/10.1183/09031936.02.00272002

• Relationship between Exhaled Nitric Oxide and Mucosal Eosinophilic Inflammation in Children with Difficult Asthma, after Treatment with Oral Prednisolone

  American Journal of Respiratory and Critical Care Medicine · 2001 · https://doi.org/10.1164/ajrccm.164.8.2101145

• Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

  The FASEB Journal · 2001 · https://doi.org/10.1096/fj.00-0432fje

• Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

  PubMed · 2001

• Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

  Molecular and Cellular Biology · 2000 · https://doi.org/10.1128/mcb.20.18.6891-6903.2000

• Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

  American Journal of Respiratory and Critical Care Medicine · 1998 · https://doi.org/10.1164/ajrccm.158.5.9706116

• Anti-inflammatory actions of steroids: molecular mechanisms

  Trends in Pharmacological Sciences · 1993 · https://doi.org/10.1016/0165-6147(93)90184-l

Current projects

No projects listed.