Thomas Klockgether

Research interests

Publications

• Natural History, Phenotypic Spectrum, and Discriminative Features of Multisystemic RFC1 Disease

  Neurology · 2021 · https://doi.org/10.1212/wnl.0000000000011528

• Spinocerebellar ataxia

  Nature Reviews Disease Primers · 2019 · 10.1038/s41572-019-0074-3

• Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients

  Annals of Neurology · 2016 · 10.1002/ana.24611

• Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study

  The Lancet Neurology · 2015 · 10.1016/s1474-4422(15)00202-1

• The natural history of multiple system atrophy: a prospective European cohort study

  The Lancet Neurology · 2013 · https://doi.org/10.1016/s1474-4422(12)70327-7

• Leitlinien für Diagnostik und Therapie in der Neurologie

  Journal · 2012 · https://doi.org/10.1055/b-002-37755

• Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease

  Nature · 2011 · 10.1038/nature10671

• Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

  Neuron · 2011 · 10.1016/j.neuron.2011.07.001

• Presentation, diagnosis, and management of multiple system atrophy in Europe: Final analysis of the European multiple system atrophy registry

  Movement Disorders · 2010 · https://doi.org/10.1002/mds.23192

• The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

  The Journal of Experimental Medicine · 2009 · 10.1084/jem.20082771

• Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism

  Journal of Neuroinflammation · 2008 · 10.1186/1742-2094-5-38

• Second consensus statement on the diagnosis of multiple system atrophy

  Neurology · 2008 · https://doi.org/10.1212/01.wnl.0000324625.00404.15

• Red flags for multiple system atrophy

  Movement Disorders · 2008 · https://doi.org/10.1002/mds.21992

• Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0503839103

• Scale for the assessment and rating of ataxia

  Neurology · 2006 · https://doi.org/10.1212/01.wnl.0000219042.60538.92

• Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

  International Journal of Developmental Neuroscience · 2006 · 10.1016/j.ijdevneu.2005.11.014

• Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice

  Journal of Neuroscience · 2006 · 10.1523/jneurosci.4236-05.2006

• Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

  Journal of Neuroinflammation · 2005 · 10.1186/1742-2094-2-22

• Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

  Brain · 2005 · 10.1093/brain/awh452

• Primary Central Nervous System Lymphoma: Results of a Pilot and Phase II Study of Systemic and Intraventricular Chemotherapy With Deferred Radiotherapy

  Journal of Clinical Oncology · 2003 · https://doi.org/10.1200/jco.2003.04.056

• Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson's disease

  Movement Disorders · 2003 · 10.1002/mds.10417

• Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase

  Journal of Neuroscience · 2003 · 10.1523/jneurosci.23-30-09796.2003

• Consensus statement on the diagnosis of multiple system atrophy

  Journal of the Neurological Sciences · 1999 · https://doi.org/10.1016/s0022-510x(98)00304-9

• The phenotypic spectrum of CADASIL: Clinical findings in 102 cases

  Annals of Neurology · 1998 · https://doi.org/10.1002/ana.410440506

• The natural history of degenerative ataxia: a retrospective study in 466 patients

  Brain · 1998 · 10.1093/brain/121.4.589

• Consensus statement on the diagnosis of multiple system atrophy

  Clinical Autonomic Research · 1998 · https://doi.org/10.1007/bf02309628

• An Isoform of Ataxin‐3 Accumulates in the Nucleus of Neuronal Cells in Affected Brain Regions of SCA3 Patients

  Brain Pathology · 1998 · https://doi.org/10.1111/j.1750-3639.1998.tb00193.x

• Molecular and Clinical Correlations in Spinocerebellar Ataxia 2: A Study of 32 Families

  Human Molecular Genetics · 1997 · https://doi.org/10.1093/hmg/6.5.709

• Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

  Journal of Neuroscience · 1996 · 10.1523/jneurosci.16-15-04696.1996

• Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23–24.1

  Nature Genetics · 1993 · https://doi.org/10.1038/ng0793-295

Current projects

No projects listed.