Christian Trautwein

Research interests

Publications

• Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

  Journal of Hepatology · 2020 · https://doi.org/10.1016/j.jhep.2020.02.027

• Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

  Gastroenterology · 2020 · 10.1053/j.gastro.2020.06.021

• The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

  Journal of Hepatology · 2020 · https://doi.org/10.1016/j.jhep.2020.06.013

• PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

  Journal of Hepatology · 2020 · https://doi.org/10.1016/j.jhep.2020.11.019

• Pan-cancer image-based detection of clinically actionable genetic alterations

  Nature Cancer · 2020 · 10.1038/s43018-020-0087-6

• Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0462-y

• Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

  Journal of Hepatology · 2018 · https://doi.org/10.1016/j.jhep.2018.05.036

• Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

  Hepatology · 2017 · 10.1002/hep.29544

• Liver — guardian, modifier and target of sepsis

  Nature Reviews Gastroenterology & Hepatology · 2016 · 10.1038/nrgastro.2016.168

• Liver inflammation abrogates immunological tolerance induced by Kupffer cells

  Hepatology · 2015 · 10.1002/hep.27793

• Hepatic fibrosis: Concept to treatment

  Journal of Hepatology · 2015 · 10.1016/j.jhep.2015.02.039

• Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

  Fibrogenesis & Tissue Repair · 2013 · https://doi.org/10.1186/1755-1536-6-19

• Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

  Gut · 2011 · 10.1136/gutjnl-2011-300304

• Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

  Hepatology · 2010 · 10.1002/hep.23922

• Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

  The Journal of Experimental Medicine · 2010 · 10.1084/jem.20091474

• Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

  BMC Immunology · 2010 · 10.1186/1471-2172-11-30

• Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis #

  Hepatology · 2009 · 10.1002/hep.22950

• Inflammatory Pathways in Liver Homeostasis and Liver Injury

  Clinical Reviews in Allergy & Immunology · 2008 · 10.1007/s12016-008-8091-0

• Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

  Cancer Cell · 2007 · 10.1016/j.ccr.2006.12.016

• STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo

  Gastroenterology · 2006 · https://doi.org/10.1053/j.gastro.2006.10.018

• Met provides essential signals for liver regeneration

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0403412101

• Impact of Interleukin-6 on Plaque Development and Morphology in Experimental Atherosclerosis

  Circulation · 2004 · 10.1161/01.cir.0000148135.08582.97

• Caspase 8 small interfering RNA prevents acute liver failure in mice

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.1330920100

• Treatment of Acute Hepatitis C with Interferon Alfa-2b

  New England Journal of Medicine · 2001 · https://doi.org/10.1056/nejmoa011232

• Structural organization of the hepatitis B virus minichromosome

  Journal of Molecular Biology · 2001 · 10.1006/jmbi.2000.4481

• The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and CytochromecRelease

  Molecular and Cellular Biology · 1998 · 10.1128/mcb.18.11.6353

• I. TNF-induced liver injury

  American Journal of Physiology-Gastrointestinal and Liver Physiology · 1998 · 10.1152/ajpgi.1998.275.3.g387

• Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

  Nature · 1993 · 10.1038/364544a0

Current projects

No projects listed.