Norbert Frey

Research interests

Publications

• A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

  Signal Transduction and Targeted Therapy · 2024 · 10.1038/s41392-024-01946-6

• Transcatheter or Surgical Treatment of Aortic-Valve Stenosis

  New England Journal of Medicine · 2024 · https://doi.org/10.1056/nejmoa2400685

• 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

  European Heart Journal · 2021 · https://doi.org/10.1093/eurheartj/ehab368

• Comparison of newer generation self-expandable vs. balloon-expandable valves in transcatheter aortic valve implantation: the randomized SOLVE-TAVI trial

  European Heart Journal · 2020 · 10.1093/eurheartj/ehaa036

• Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation

  Circulation · 2020 · 10.1161/circulationaha.120.048792

• Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

  Nature Communications · 2020 · 10.1038/s41467-020-19230-w

• Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

  Immunity · 2020 · https://doi.org/10.1016/j.immuni.2020.11.017

• Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

  The Lancet · 2020 · https://doi.org/10.1016/s0140-6736(20)31792-x

• Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

  Human Molecular Genetics · 2017 · 10.1093/hmg/ddx283

• Heart Failure is Associated with Depletion of Core Intestinal Microbiota

  ESC Heart Failure · 2017 · 10.1002/ehf2.12155

• Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

  CPT Pharmacometrics & Systems Pharmacology · 2015 · 10.1002/psp4.12049

• Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy

  Cell Metabolism · 2015 · https://doi.org/10.1016/j.cmet.2015.09.002

• RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

  Cardiovascular Research · 2014 · 10.1093/cvr/cvu146

• Mechanisms of disease: hypertrophic cardiomyopathy

  Nature Reviews Cardiology · 2011 · 10.1038/nrcardio.2011.159

• The sarcomeric Z-disc: a nodal point in signalling and disease

  Journal of Molecular Medicine · 2006 · 10.1007/s00109-005-0033-1

• Hypertrophy of the Heart

  Circulation · 2004 · https://doi.org/10.1161/01.cir.0000120390.68287.bb

• Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

  Nature Medicine · 2004 · 10.1038/nm1132

• Cardiac Hypertrophy: The Good, the Bad, and the Ugly

  Annual Review of Physiology · 2003 · https://doi.org/10.1146/annurev.physiol.65.092101.142243

• Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

  Proceedings of the National Academy of Sciences · 2002 · 10.1073/pnas.231619298

• Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy

  The EMBO Journal · 2001 · 10.1093/emboj/20.11.2757

• Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A

  Circulation Research · 2001 · 10.1161/hh2301.100003

• CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

  Journal of Clinical Investigation · 2000 · 10.1172/jci8551

• Calsarcins, a novel family of sarcomeric calcineurin-binding proteins

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.260501097

• Decoding calcium signals involved in cardiac growth and function

  Nature Medicine · 2000 · 10.1038/81321

• Independent Signals Control Expression of the Calcineurin Inhibitory Proteins MCIP1 and MCIP2 in Striated Muscles

  Circulation Research · 2000 · 10.1161/01.res.87.12.e61

Current projects

No projects listed.