Claudia Haferlach

Research interests

Publications

• Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma

  Nature Medicine · 2023 · https://doi.org/10.1038/s41591-023-02491-5

• Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma

  Nature Medicine · 2021 · 10.1038/s41591-021-01245-5

• Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

  Blood · 2017 · https://doi.org/10.1182/blood-2016-12-754796

• Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants

  Leukemia · 2017 · https://doi.org/10.1038/leu.2017.253

• Dynamics of clonal evolution in myelodysplastic syndromes

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3742

• Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia

  Blood · 2016 · 10.1182/blood-2016-05-714030

• Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

  Nature · 2014 · https://doi.org/10.1038/nature13115

• Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

  Cell stem cell · 2014 · https://doi.org/10.1016/j.stem.2014.02.014

• Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes

  Blood · 2013 · https://doi.org/10.1182/blood.v122.21.521.521

• Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

  Nature Genetics · 2013 · 10.1038/ng.2731

• Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

  Leukemia · 2013 · https://doi.org/10.1038/leu.2013.336

• Deep Molecular Response Is Reached by the Majority of Patients Treated With Imatinib, Predicts Survival, and Is Achieved More Quickly by Optimized High-Dose Imatinib: Results From the Randomized CML-Study IV

  Journal of Clinical Oncology · 2013 · 10.1200/jco.2013.49.9020

• SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

  Blood · 2012 · 10.1182/blood-2012-01-404863

• Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML)

  Leukemia · 2012 · 10.1038/leu.2012.85

• Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV

  Blood · 2011 · 10.1182/blood-2011-08-373902

• BRAF Mutations in Hairy-Cell Leukemia

  New England Journal of Medicine · 2011 · https://doi.org/10.1056/nejmoa1014209

• Frequent pathway mutations of splicing machinery in myelodysplasia

  Nature · 2011 · https://doi.org/10.1038/nature10496

• Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

  Blood · 2011 · https://doi.org/10.1182/blood-2011-07-365320

• Tolerability-Adapted Imatinib 800 mg/d Versus 400 mg/d Versus 400 mg/d Plus Interferon-α in Newly Diagnosed Chronic Myeloid Leukemia

  Journal of Clinical Oncology · 2011 · 10.1200/jco.2010.32.0598

• Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

  Journal of Clinical Oncology · 2010 · 10.1200/jco.2009.27.1361

• Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes

  The Lancet · 2010 · https://doi.org/10.1016/s0140-6736(10)62105-8

• Minimal residual disease levels assessed by NPM1 mutation–specific RQ-PCR provide important prognostic information in AML

  Blood · 2009 · 10.1182/blood-2009-03-213389

• Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

  Blood · 2009 · https://doi.org/10.1182/blood-2009-03-208397

• Age-Related Risk Profile and Chemotherapy Dose Response in Acute Myeloid Leukemia: A Study by the German Acute Myeloid Leukemia Cooperative Group

  Journal of Clinical Oncology · 2008 · https://doi.org/10.1200/jco.2007.15.4245

• Prognostic relevance of FLT3-TKD mutations in AML: the combination matters—an analysis of 3082 patients

  Blood · 2007 · https://doi.org/10.1182/blood-2007-05-091215

• Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgVH status and immunophenotyping

  Leukemia · 2007 · 10.1038/sj.leu.2404935

Current projects

No projects listed.