Wolfgang Kern

Research interests

Publications

• 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

  Blood · 2021 · https://doi.org/10.1182/blood.2021013626

• Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic Features in Myelodysplastic Syndromes

  Journal of Clinical Oncology · 2021 · https://doi.org/10.1200/jco.20.01659

• Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms

  Blood · 2020 · https://doi.org/10.1182/blood.2019004229

• TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

  Leukemia · 2019 · https://doi.org/10.1038/s41375-018-0351-2

• Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

  Blood · 2017 · https://doi.org/10.1182/blood-2016-12-754796

• Dynamics of clonal evolution in myelodysplastic syndromes

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3742

• Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

  Leukemia · 2013 · https://doi.org/10.1038/leu.2013.336

• Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes

  Blood · 2013 · https://doi.org/10.1182/blood.v122.21.521.521

• BRAF Mutations in Hairy-Cell Leukemia

  New England Journal of Medicine · 2011 · https://doi.org/10.1056/nejmoa1014209

• Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

  Blood · 2011 · https://doi.org/10.1182/blood-2011-07-365320

• High dose ara-C in the treatment of newly diagnosed acute promyelocytic leukemia: long-term results of the German AMLCG

  Leukemia · 2009 · https://doi.org/10.1038/leu.2009.183

• Age-Related Risk Profile and Chemotherapy Dose Response in Acute Myeloid Leukemia: A Study by the German Acute Myeloid Leukemia Cooperative Group

  Journal of Clinical Oncology · 2008 · https://doi.org/10.1200/jco.2007.15.4245

• Prognostic relevance of FLT3-TKD mutations in AML: the combination matters—an analysis of 3082 patients

  Blood · 2007 · https://doi.org/10.1182/blood-2007-05-091215

• Double Induction Containing Either Two Courses or One Course of High-Dose Cytarabine Plus Mitoxantrone and Postremission Therapy by Either Autologous Stem-Cell Transplantation or by Prolonged Maintenance for Acute Myeloid Leukemia

  Journal of Clinical Oncology · 2006 · https://doi.org/10.1200/jco.2005.04.5013

• KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

  Blood · 2005 · https://doi.org/10.1182/blood-2005-04-1466

• Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

  Blood · 2005 · https://doi.org/10.1182/blood-2005-06-2248

• The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

  Journal of Clinical Investigation · 2005 · https://doi.org/10.1172/jci24225

• Global approach to the diagnosis of leukemia using gene expression profiling

  Blood · 2005 · https://doi.org/10.1182/blood-2004-12-4938

• Prognostic impact of RT-PCR-based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukemia

  Leukemia · 2005 · https://doi.org/10.1038/sj.leu.2403809

• Determination of relapse risk based on assessment of minimal residual disease during complete remission by multiparameter flow cytometry in unselected patients with acute myeloid leukemia

  Blood · 2004 · https://doi.org/10.1182/blood-2004-03-1036

• Prognosis in Therapy-Related Acute Myeloid Leukemia and Impact of Karyotype

  Journal of Clinical Oncology · 2004 · https://doi.org/10.1200/jco.2004.99.301

• Molecular characterization of acute leukemias by use of microarray technology

  Genes Chromosomes and Cancer · 2003 · https://doi.org/10.1002/gcc.10225

• 6-Thioguanine, Cytarabine, and Daunorubicin (TAD) and High-Dose Cytarabine and Mitoxantrone (HAM) for Induction, TAD for Consolidation, and Either Prolonged Maintenance by Reduced Monthly TAD or TAD-HAM-TAD and One Course of Intensive Consolidation by Sequential HAM in Adult Patients at All Ages With De Novo Acute Myeloid Leukemia (AML): A Randomized Trial of the German AML Cooperative Group

  Journal of Clinical Oncology · 2003 · https://doi.org/10.1200/jco.2003.02.133

• Karyotype is an independent prognostic parameter in therapy-related acute myeloid leukemia (t-AML): an analysis of 93 patients with t-AML in comparison to 1091 patients with de novo AML

  Leukemia · 2003 · https://doi.org/10.1038/sj.leu.2403187

• New score predicting for prognosis in PML-RARA+, AML1-ETO+, or CBFBMYH11+ acute myeloid leukemia based on quantification of fusion transcripts

  Blood · 2003 · https://doi.org/10.1182/blood-2003-03-0880

• Morphologic Dysplasia in De Novo Acute Myeloid Leukemia (AML) Is Related to Unfavorable Cytogenetics but Has No Independent Prognostic Relevance Under the Conditions of Intensive Induction Therapy: Results of a Multiparameter Analysis From the German AML Cooperative Group Studies

  Journal of Clinical Oncology · 2003 · https://doi.org/10.1200/jco.2003.08.005

• AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases

  Blood · 2003 · https://doi.org/10.1182/blood-2003-02-0434

• Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

  Blood · 2002 · https://doi.org/10.1182/blood.v100.1.59

• Early blast clearance by remission induction therapy is a major independent prognostic factor for both achievement of complete remission and long-term outcome in acute myeloid leukemia: data from the German AML Cooperative Group (AMLCG) 1992 Trial

  Blood · 2002 · https://doi.org/10.1182/blood-2002-02-0532

• Management of Acute Myeloid Leukemia in Elderly Patients

  Journal of Clinical Oncology · 1999 · https://doi.org/10.1200/jco.1999.17.11.3569

Current projects

No projects listed.