Carsten Müller‐Tidow

Research interests

Publications

• A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

  Nature Medicine · 2023 · 10.1038/s41591-023-02234-6

• The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients

  Cancer Cell · 2023 · https://doi.org/10.1016/j.ccell.2023.02.008

• Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

  Blood · 2022 · https://doi.org/10.1182/blood.2022018221

• Side-effect management of chimeric antigen receptor (CAR) T-cell therapy

  Annals of Oncology · 2020 · 10.1016/j.annonc.2020.10.478

• AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

  Nature Cell Biology · 2017 · https://doi.org/10.1038/ncb3563

• Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

  Nature Medicine · 2016 · 10.1038/nm.4247

• Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trial

  The Lancet Oncology · 2015 · https://doi.org/10.1016/s1470-2045(15)00362-9

• PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups

  PLoS ONE · 2015 · 10.1371/journal.pone.0136023

• Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.03.017

• Sorafenib in Combination With Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial

  Journal of Clinical Oncology · 2013 · 10.1200/jco.2012.46.4990

• Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2661

• Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

  Blood · 2011 · 10.1182/blood-2010-12-326843

• Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages

  Arteriosclerosis Thrombosis and Vascular Biology · 2011 · 10.1161/atvbaha.111.222745

• The Long Noncoding MALAT-1 RNA Indicates a Poor Prognosis in Non-small Cell Lung Cancer and Induces Migration and Tumor Growth

  Journal of Thoracic Oncology · 2011 · 10.1097/jto.0b013e3182307eac

• Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes

  The Lancet · 2010 · https://doi.org/10.1016/s0140-6736(10)62105-8

• EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0810759106

• Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

  Molecular Cell · 2009 · 10.1016/j.molcel.2009.09.019

• Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia

  Blood · 2009 · 10.1182/blood-2009-08-240101

• Age-Related Risk Profile and Chemotherapy Dose Response in Acute Myeloid Leukemia: A Study by the German Acute Myeloid Leukemia Cooperative Group

  Journal of Clinical Oncology · 2008 · https://doi.org/10.1200/jco.2007.15.4245

• AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations

  Blood · 2005 · 10.1182/blood-2004-07-2942

• Constitutive Activation of Akt by Flt3 Internal Tandem Duplications Is Necessary for Increased Survival, Proliferation, and Myeloid Transformation

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-0422

• S100 Family Members and Trypsinogens Are Predictors of Distant Metastasis and Survival in Early-Stage Non-Small Cell Lung Cancer

  Cancer Research · 2004 · https://doi.org/10.1158/0008-5472.can-04-2004

• Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells

  Molecular and Cellular Biology · 2004 · 10.1128/mcb.24.7.2890-2904.2004

• MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer

  Oncogene · 2003 · 10.1038/sj.onc.1206928

• Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

  Blood · 2003 · 10.1182/blood-2002-06-1677

• The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia

  Nature Medicine · 2002 · 10.1038/nm726

• Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways

  Blood · 2000 · 10.1182/blood.v96.12.3907

• Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

  Proceedings of the National Academy of Sciences · 1998 · 10.1073/pnas.95.15.8806

Current projects

No projects listed.