Paul Hofman

Research interests

Publications

• Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists

  Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 2020 · https://doi.org/10.1007/s00428-020-02886-6

• The association of PD-L1 expression with the efficacy of anti-PD-1/PD-L1 immunotherapy and survival of non-small cell lung cancer patients: a meta-analysis of randomized controlled trials

  Translational Lung Cancer Research · 2019 · https://doi.org/10.21037/tlcr.2019.08.09

• Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

  Cell Metabolism · 2018 · https://doi.org/10.1016/j.cmet.2018.09.012

• Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

  Scientific Reports · 2016 · https://doi.org/10.1038/srep19032

• Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.04.013

• Pros: Can tissue biopsy be replaced by liquid biopsy?

  Translational Lung Cancer Research · 2016 · https://doi.org/10.21037/tlcr.2016.08.06

• Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients

  Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 2016 · https://doi.org/10.1007/s00428-016-1910-4

• Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies

  Annals of Oncology · 2015 · https://doi.org/10.1093/annonc/mdv489

• “Sentinel” Circulating Tumor Cells Allow Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease

  PLoS ONE · 2014 · https://doi.org/10.1371/journal.pone.0111597

• Two Panels of Plasma MicroRNAs as Non-Invasive Biomarkers for Prediction of Recurrence in Resectable NSCLC

  PLoS ONE · 2013 · https://doi.org/10.1371/journal.pone.0054596

• Senescent cells develop a PARP-1 and nuclear factor-κB-associated secretome (PNAS)

  Genes & Development · 2011 · https://doi.org/10.1101/gad.625811

• Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

  Oncogene · 2011 · https://doi.org/10.1038/onc.2010.598

• A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.762

• miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

  Cell Death and Differentiation · 2010 · https://doi.org/10.1038/cdd.2010.119

• Preoperative Circulating Tumor Cell Detection Using the Isolation by Size of Epithelial Tumor Cell Method for Patients with Lung Cancer Is a New Prognostic Biomarker

  Clinical Cancer Research · 2010 · https://doi.org/10.1158/1078-0432.ccr-10-0445

• Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non‐small‐cell lung carcinoma: comparison of the efficacy of the CellSearch Assay™ and the isolation by size of epithelial tumor cell method

  International Journal of Cancer · 2010 · https://doi.org/10.1002/ijc.25819

• Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

  Cancer Cell · 2008 · https://doi.org/10.1016/j.ccr.2008.11.002

• The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis

  Diabetes · 2005 · https://doi.org/10.2337/diabetes.54.2.402

• Relearning sound localization with new ears

  Nature Neuroscience · 1998 · https://doi.org/10.1038/1633

Current projects

No projects listed.