Paul Brennan

Research interests

Publications

• Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

  Cell Genomics · 2022 · https://doi.org/10.1016/j.xgen.2022.100179

• Whole-genome sequencing of patients with rare diseases in a national health system

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2434-2

• Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial

  The Lancet · 2019 · https://doi.org/10.1016/s0140-6736(19)31791-x

• Prediction of acute myeloid leukaemia risk in healthy individuals

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0317-6

• Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-02942-5

• Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases

  JAMA Oncology · 2017 · https://doi.org/10.1001/jamaoncol.2016.5945

• Association analysis identifies 65 new breast cancer risk loci

  Nature · 2017 · https://doi.org/10.1038/nature24284

• Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study

  PLoS ONE · 2017 · https://doi.org/10.1371/journal.pone.0177875

• High prevalence of mutantKRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients

  Annals of Oncology · 2017 · https://doi.org/10.1093/annonc/mdx004

• The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers

  Cancer Epidemiology Biomarkers & Prevention · 2016 · https://doi.org/10.1158/1055-9965.epi-16-0106

• Genome-wide association study reveals two new risk loci for bipolar disorder

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms4339

• Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.3002

• Evaluation of Human Papillomavirus Antibodies and Risk of Subsequent Head and Neck Cancer

  Journal of Clinical Oncology · 2013 · https://doi.org/10.1200/jco.2012.47.2738

• Cigarette smoking and lung cancer—relative risk estimates for the major histological types from a pooled analysis of case–control studies

  International Journal of Cancer · 2011 · https://doi.org/10.1002/ijc.27339

• A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

  The American Journal of Human Genetics · 2011 · https://doi.org/10.1016/j.ajhg.2011.05.003

• A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.687

• A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

  The American Journal of Human Genetics · 2009 · https://doi.org/10.1016/j.ajhg.2009.09.012

• Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

  Cancer Epidemiology Biomarkers & Prevention · 2009 · https://doi.org/10.1158/1055-9965.epi-08-0347

• Lung cancer susceptibility locus at 5p15.33

  Nature Genetics · 2008 · https://doi.org/10.1038/ng.254

• Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors

  Clinical Cancer Research · 2008 · https://doi.org/10.1158/1078-0432.ccr-07-4921

• Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium

  Clinical Gastroenterology and Hepatology · 2008 · https://doi.org/10.1016/j.cgh.2008.02.011

• Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium

  Blood · 2008 · https://doi.org/10.1182/blood-2007-10-119974

• A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

  Nature · 2008 · https://doi.org/10.1038/nature06885

• A common coding variant in CASP8 is associated with breast cancer risk

  Nature Genetics · 2007 · https://doi.org/10.1038/ng1981

• Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium

  The Lancet Oncology · 2005 · https://doi.org/10.1016/s1470-2045(05)70434-4

Current projects

No projects listed.