Ivan Bièche

Research interests

Publications

• Recommendations for the use of next-generation sequencing (NGS) for patients with advanced cancer in 2024: a report from the ESMO Precision Medicine Working Group

  Annals of Oncology · 2024 · https://doi.org/10.1016/j.annonc.2024.04.005

• Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial

  The Lancet Oncology · 2022 · 10.1016/s1470-2045(22)00555-1

• Durvalumab compared to maintenance chemotherapy in metastatic breast cancer: the randomized phase II SAFIR02-BREAST IMMUNO trial

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-020-01189-2

• Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group

  Annals of Oncology · 2020 · https://doi.org/10.1016/j.annonc.2020.07.014

• Outcome and molecular landscape of patients with PIK3CA-mutated metastatic breast cancer

  Annals of Oncology · 2020 · 10.1016/j.annonc.2019.11.006

• Circulating tumor DNA changes for early monitoring of anti-PD1 immunotherapy: a proof-of-concept study

  Annals of Oncology · 2017 · 10.1093/annonc/mdx212

• CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

  Brain · 2015 · 10.1093/brain/awv166

• Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

  The Lancet Oncology · 2015 · https://doi.org/10.1016/s1470-2045(15)00188-6

• Circulating tumor DNA as a non‐invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types

  Molecular Oncology · 2014 · 10.1016/j.molonc.2014.12.003

• SWI/SNF Chromatin Remodeling and Human Malignancies

  Annual Review of Pathology Mechanisms of Disease · 2014 · https://doi.org/10.1146/annurev-pathol-012414-040445

• Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: a multicentre observational study by the French ERMETIC-IFCT network

  Annals of Oncology · 2013 · 10.1093/annonc/mdt418

• Inhibitory signalling to the Arp2/3 complex steers cell migration

  Nature · 2013 · 10.1038/nature12611

• A refined molecular taxonomy of breast cancer

  Oncogene · 2011 · 10.1038/onc.2011.301

• NF1 microdeletions in neurofibromatosis type 1: from genotype to phenotype

  Human Mutation · 2010 · https://doi.org/10.1002/humu.21271

• ANRIL , a long, noncoding RNA, is an unexpected major hotspot in GWAS

  The FASEB Journal · 2010 · 10.1096/fj.10-172452

• Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues

  Pharmacogenetics and Genomics · 2007 · 10.1097/fpc.0b013e32810f2e58

• Characterization of a Germ-Line Deletion, Including the Entire INK4/ARF Locus, in a Melanoma-Neural System Tumor Family: Identification of ANRIL , an Antisense Noncoding RNA Whose Expression Coclusters with ARF

  Cancer Research · 2007 · 10.1158/0008-5472.can-06-2004

• The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

  Clinical Cancer Research · 2006 · 10.1158/1078-0432.ccr-05-1029

• Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach

  Endocrine Related Cancer · 2006 · 10.1677/erc.1.01120

• Molecular Profiling of Inflammatory Breast Cancer

  Clinical Cancer Research · 2004 · 10.1158/1078-0432.ccr-04-0306

• Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.

  PubMed · 2003

• SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers.

  PubMed · 2002

• Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays.

  PubMed · 2001

• Real-Time Reverse Transcription-PCR Assay for Future Management of ERBB2-based Clinical Applications

  Clinical Chemistry · 1999 · 10.1093/clinchem/45.8.1148

• Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay.

  PubMed · 1999

• Genetic alterations in breast cancer

  Genes Chromosomes and Cancer · 1995 · 10.1002/gcc.2870140402

Current projects

No projects listed.