Jacques Robert

Research interests

Publications

• CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics

  Nucleic Acids Research · 2020 · 10.1093/nar/gkaa968

• Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions

  Frontiers in Immunology · 2018 · 10.3389/fimmu.2018.02536

• Molecular subtypes of metastatic colorectal cancer are associated with patient response to irinotecan-based therapies

  European Journal of Cancer · 2017 · 10.1016/j.ejca.2017.02.003

• Genome evolution in the allotetraploid frog Xenopus laevis

  Nature · 2016 · https://doi.org/10.1038/nature19840

• Oxaliplatin in the era of personalized medicine: from mechanistic studies to clinical efficacy

  Cancer Chemotherapy and Pharmacology · 2015 · 10.1007/s00280-015-2901-x

• ERCC1 and ERCC2 Polymorphisms Predict Clinical Outcomes of Oxaliplatin-Based Chemotherapies in Gastric and Colorectal Cancer: A Systemic Review and Meta-analysis

  Clinical Cancer Research · 2011 · 10.1158/1078-0432.ccr-10-2169

• Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

  Mammalian Genome · 2010 · https://doi.org/10.1007/s00335-010-9284-4

• The Genome of the Western Clawed Frog Xenopus tropicalis

  Science · 2010 · https://doi.org/10.1126/science.1183670

• Innate Immune Responses and Permissiveness to Ranavirus Infection of Peritoneal Leukocytes in the FrogXenopus laevis

  Journal of Virology · 2010 · 10.1128/jvi.02486-09

• Comparative and developmental study of the immune system in Xenopus

  Developmental Dynamics · 2009 · 10.1002/dvdy.21891

• Expression Profiling the Temperature-Dependent Amphibian Response to Infection by Batrachochytrium dendrobatidis

  PLoS ONE · 2009 · 10.1371/journal.pone.0008408

• Development and characterization of a model system to study amphibian immune responses to iridoviruses

  Virology · 2003 · 10.1016/s0042-6822(03)00151-x

• Evolution of heat shock protein and immunity

  Developmental & Comparative Immunology · 2003 · https://doi.org/10.1016/s0145-305x(02)00160-x

• Correlation Between Uracil and Dihydrouracil Plasma Ratio, Fluorouracil (5-FU) Pharmacokinetic Parameters, and Tolerance in Patients With Advanced Colorectal Cancer: A Potential Interest for Predicting 5-FU Toxicity and Determining Optimal 5-FU Dosage

  Journal of Clinical Oncology · 1999 · https://doi.org/10.1200/jco.1999.17.4.1105

• Identification of a New Metabolite of CPT-11 (Irinotecan): Pharmacological Properties and Activation to SN-38

  Journal of Pharmacology and Experimental Therapeutics · 1998 · 10.1016/s0022-3565(24)37620-7

• Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions.

  PubMed · 1998

• Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients.

  Journal of Clinical Oncology · 1998 · 10.1200/jco.1998.16.4.1470

• Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials.

  PubMed · 1997

• Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients.

  PubMed · 1996

• Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

  Biochemical Pharmacology · 1996 · 10.1016/0006-2952(96)00457-1

• Identification and kinetics of a ?-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan

  Cancer Chemotherapy and Pharmacology · 1995 · 10.1007/bf00689205

• Standardization of the rainflow counting method for fatigue analysis

  International Journal of Fatigue · 1994 · https://doi.org/10.1016/0142-1123(94)90343-3

• Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture

  European Journal of Cancer · 1994 · 10.1016/s0959-8049(05)80025-5

• Pharmacokinetics and metabolism of anthracyclines.

  PubMed · 1993

• Right ventricular overload and induced sustained ventricular tachycardia in operatively “repaired” tetralogy of Fallot

  The American Journal of Cardiology · 1992 · 10.1016/0002-9149(92)90506-t

• Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

  Journal of Allergy and Clinical Immunology · 1991 · https://doi.org/10.1016/0091-6749(91)90213-8

• Age‐related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population

  American Journal of Medical Genetics · 1989 · https://doi.org/10.1002/ajmg.1320320302

Current projects

No projects listed.